The rat-brain postsynaptic density fraction contains a homolog of the drosophila disk-large tumor supressor protein

Cited 960 time in webofscience Cited 0 time in scopus
  • Hit : 295
  • Download : 0
DC FieldValueLanguage
dc.contributor.authorCho, Kyungokko
dc.contributor.authorHUNT, Carol A.ko
dc.contributor.authorKENNEDY, Mary B.ko
dc.date.accessioned2013-02-24T12:49:49Z-
dc.date.available2013-02-24T12:49:49Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued1992-11-
dc.identifier.citationNEURON, v.9, no.5, pp.929 - 942-
dc.identifier.issn0896-6273-
dc.identifier.urihttp://hdl.handle.net/10203/57266-
dc.description.abstractIn CNS synapses, the synaptic junctional complex with associated postsynaptic density is presumed to contain proteins responsible for adhesion between pre- and postsynaptic membranes and for postsynaptic signal transduction. We have found that a prominent, brain-specific protein (PSD-95) enriched in the postsynaptic density fraction from rat brain is highly similar to the Drosophila lethal(1)discs-large-1 (dlg) tumor suppressor protein. The dlg protein is associated with septate junctions in developing flies and contains a guanylate kinase domain that is required for normal control of cell division. The sequence similarity between dlg and PSD-95 suggests that molecular mechanisms critical for growth control in developing organisms may also regulate synapse formation, stabilization, or function in the adult brain.-
dc.languageEnglish-
dc.publisherCELL PRESS-
dc.subjectLONG-TERM POTENTIATION-
dc.subjectCENTRAL NERVOUS-SYSTEM-
dc.subjectAMINO-ACID SEQUENCE-
dc.subjectSIGNAL TRANSDUCTION-
dc.subjectGUANYLATE KINASE-
dc.subjectBINDING PROTEIN-
dc.subjectCALMODULIN-
dc.subjectDNA-
dc.subjectIDENTIFICATION-
dc.subjectJUNCTIONS-
dc.titleThe rat-brain postsynaptic density fraction contains a homolog of the drosophila disk-large tumor supressor protein-
dc.typeArticle-
dc.identifier.wosidA1992JY55200012-
dc.identifier.scopusid2-s2.0-0026492629-
dc.type.rimsART-
dc.citation.volume9-
dc.citation.issue5-
dc.citation.beginningpage929-
dc.citation.endingpage942-
dc.citation.publicationnameNEURON-
dc.identifier.doi10.1016/0896-6273(92)90245-9-
dc.contributor.localauthorCho, Kyungok-
dc.contributor.nonIdAuthorHUNT, Carol A.-
dc.contributor.nonIdAuthorKENNEDY, Mary B.-
dc.type.journalArticleArticle-
dc.subject.keywordPlusLONG-TERM POTENTIATION-
dc.subject.keywordPlusCENTRAL NERVOUS-SYSTEM-
dc.subject.keywordPlusAMINO-ACID SEQUENCE-
dc.subject.keywordPlusSIGNAL TRANSDUCTION-
dc.subject.keywordPlusGUANYLATE KINASE-
dc.subject.keywordPlusBINDING PROTEIN-
dc.subject.keywordPlusCALMODULIN-
dc.subject.keywordPlusDNA-
dc.subject.keywordPlusIDENTIFICATION-
dc.subject.keywordPlusJUNCTIONS-
Appears in Collection
BS-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 960 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0