Distinct roles of striatal direct and indirect pathways in value-based decision making

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The striatum is critically involved in value-based decision making. However, it is unclear how striatal direct and indirect pathways work together to make optimal choices in a dynamic and uncertain environment. Here, we examined the effects of selectively inactivating D1 receptor (D1R)- or D2 receptor (D2R)-expressing dorsal striatal neurons (corresponding to direct-and indirect-pathway neurons, respectively) on mouse choice behavior in a reversal task with progressively increasing reversal frequency and a dynamic two-armed bandit task. Inactivation of either D1R- or D2R-expressing striatal neurons impaired performance in both tasks, but the pattern of altered choice behavior differed between the two animal groups. A reinforcement learning model-based analysis indicated that inactivation of D1R- and D2R-expressing striatal neurons selectively impairs value-dependent action selection and value learning, respectively. Our results suggest differential contributions of striatal direct and indirect pathways to two distinct steps in value-based decision making.
Publisher
ELIFE SCIENCES PUBLICATIONS LTD
Issue Date
2019-07
Language
English
Article Type
Article
Citation

ELIFE, v.8, pp.1 - 16

ISSN
2050-084X
DOI
10.7554/eLife.46050
URI
http://hdl.handle.net/10203/264358
Appears in Collection
BS-Journal Papers(저널논문)
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