Role of the hippocampal CA1 region in incremental value learning

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It is generally believed that the hippocampus plays a crucial role in declarative memory-remembering facts and events-but not in gradual stimulus-response association or incremental value learning. Based on the finding that CA1 conveys strong value signals during dynamic foraging, we investigated the possibility that the hippocampus contributes to incremental value learning. Specifically, we examined effects of inactivating different subregions of the dorsal hippocampus on behavioral performance of mice performing a dynamic foraging task in a modified T-maze. A reinforcement learning model-based analysis indicated that inactivation of CA1, but not dentate gyrus, CA3, or CA2, impaired trial-by-trial updating of chosen value without affecting value-dependent action selection. As a result, it took longer for CA1-inactivated mice to bias their choices toward the higher-reward-probability target after changes in reward probability. Our results indicate, contrary to the traditional view, that the hippocampus, especially CA1, might contribute to incremental value learning under certain circumstances.
Publisher
NATURE PUBLISHING GROUP
Issue Date
2018-06
Language
English
Article Type
Article
Keywords

EYEBLINK CONDITIONED-RESPONSES; MEDIAL PREFRONTAL CORTEX; LONG-TERM POTENTIATION; ORBITOFRONTAL CORTEX; DECISION-MAKING; MEMORY-SYSTEMS; BASAL GANGLIA; MULTIPLE REPRESENTATIONS; DORSAL HIPPOCAMPUS; CINGULATE CORTEX

Citation

SCIENTIFIC REPORTS, v.8

ISSN
2045-2322
DOI
10.1038/s41598-018-28176-5
URI
http://hdl.handle.net/10203/244560
Appears in Collection
BS-Journal Papers(저널논문)
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