Genetic incorporation of L-dihydroxyphenylalanine (DOPA) biosynthesized by a tyrosine phenol-lyase
L-Dihydroxyphenylalanine (DOPA) was biosynthesized by a tyrosine-phenol lyase from catechol, pyruvate, and ammonia in Escherichia coli, and the biosynthesized amino acid was directly incorporated into proteins. Three biochemical experiments with mutant proteins containing DOPA confirmed the genetic incorporation of biosynthesized DOPA, and revealed its potential for various biochemical applications.
- Publisher
- ROYAL SOC CHEMISTRY
- Issue Date
- 2018-03
- Language
- English
- Article Type
- Article
- Keywords
UNNATURAL AMINO-ACIDS; TRANSFER-RNA SYNTHETASES; PROTEIN CROSS-LINKING; ESCHERICHIA-COLI; STRUCTURAL BASIS; CODE; EVOLUTION; 3,4-DIHYDROXYPHENYL-L-ALANINE; CONJUGATION
- Citation
CHEMICAL COMMUNICATIONS, v.54, no.24, pp.3002 - 3005
- ISSN
- 1359-7345
- Appears in Collection
- BS-Journal Papers(저널논문)
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