Ultrasound-mediated drug delivery by gas bubbles generated from a chemical reaction

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Highly echogenic and ultrasound-responsive microbubbles such as nitrogen and perfluorocarbons have been exploited as ultrasound-mediated drug carriers. Here, we propose an innovative method for drug delivery using microbubbles generated from a chemical reaction. In a novel drug delivery system, luminol encapsulated in folate-conjugated bovine serum albumin nanoparticles (Fol-BSAN) can generate nitrogen gas (N-2) by chemical reaction when it reacts with hydrogen peroxide (H2O2), one of reactive oxygen species (ROS). ROS plays an important role in the initiation and progression of cancer and elevated ROS have been observed in cancer cells both in vitro and in vivo. High-intensity focussed ultrasound (HIFU) is used to burst the N-2 microbubbles, causing site-specific delivery of anticancer drugs such as methotrexate. In this research, the drug delivery system was optimised by using water-soluble luminol and Mobil Composition of Matter-41 (MCM-41), a mesoporous material, so that the delivery system was sensitive to micromolar concentrations of H2O2. HIFU increased the drug release from Fol-BSAN by 52.9 +/- 2.9% in 10minutes. The cytotoxicity of methotrexate was enhanced when methotrexate is delivered to MDA-MB-231, a metastatic human breast cancer cell line, using Fol-BSAN with HIFU. We anticipate numerous applications of chemically generated microbubbles for ultrasound-mediated drug delivery.
Publisher
TAYLOR & FRANCIS LTD
Issue Date
2018-01
Language
English
Article Type
Article
Keywords

MICROBUBBLE CONTRAST AGENTS; OXIDATIVE STRESS; CANCER-TREATMENT; GENE DELIVERY; IN-VIVO; THERAPY; METHOTREXATE; MONODISPERSE; CAVITATION; MECHANISMS

Citation

JOURNAL OF DRUG TARGETING, v.26, no.2, pp.172 - 181

ISSN
1061-186X
DOI
10.1080/1061186X.2017.1354001
URI
http://hdl.handle.net/10203/240233
Appears in Collection
BiS-Journal Papers(저널논문)CBE-Journal Papers(저널논문)
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