DC Field | Value | Language |
---|---|---|
dc.contributor.author | Won, Seoung Youn | ko |
dc.contributor.author | Kim, Cha Yeon | ko |
dc.contributor.author | Kim, Doyoun | ko |
dc.contributor.author | Ko, Jaewon | ko |
dc.contributor.author | Um, Ji Won | ko |
dc.contributor.author | Lee, Sung Bae | ko |
dc.contributor.author | Buck, Matthias | ko |
dc.contributor.author | Kim, Eunjoon | ko |
dc.contributor.author | Heo, Won Do | ko |
dc.contributor.author | Lee, Jie-Oh | ko |
dc.contributor.author | Kim, Ho Min | ko |
dc.date.accessioned | 2017-11-08T05:04:39Z | - |
dc.date.available | 2017-11-08T05:04:39Z | - |
dc.date.created | 2017-10-30 | - |
dc.date.created | 2017-10-30 | - |
dc.date.created | 2017-10-30 | - |
dc.date.created | 2017-10-30 | - |
dc.date.created | 2017-10-30 | - |
dc.date.issued | 2017-10 | - |
dc.identifier.citation | FRONTIERS IN MOLECULAR NEUROSCIENCE, v.10, pp.327 | - |
dc.identifier.issn | 1662-5099 | - |
dc.identifier.uri | http://hdl.handle.net/10203/226823 | - |
dc.description.abstract | The leukocyte common antigen-related receptor protein tyrosine phosphatases (LAR-RPTPs) are cellular receptors of heparan sulfate (HS) and chondroitin sulfate (CS) proteoglycans that direct axonal growth and neuronal regeneration. LAR-RPTPs are also synaptic adhesion molecules that form trans-synaptic adhesion complexes by binding to various postsynaptic adhesion ligands, such as Slit-and Trk-like family of proteins (Slitrks), IL-1 receptor accessory protein-like 1 (IL1RAPL1), interleukin-1 receptor accessory protein (IL-1RAcP) and neurotrophin receptor tyrosine kinase C (TrkC), to regulate synaptogenesis. Here, we determined the crystal structure of the human LAR-RPTP/IL1RAPL1 complex and found that lateral interactions between neighboring LAR-RPTP/IL1RAPL1 complexes in crystal lattices are critical for the higher-order assembly and synaptogenic activity of these complexes. Moreover, we found that LAR-RPTP binding to the postsynaptic adhesion ligands, Slitrk3, IL1RAPL1 and IL-1RAcP, but not TrkC, induces reciprocal higher-order clustering of trans-synaptic adhesion complexes. Although LAR-RPTP clustering was induced by either HS or postsynaptic adhesion ligands, the dominant binding of HS to the LAR-RPTP was capable of dismantling pre-established LAR-RPTP-mediated trans-synaptic adhesion complexes. These findings collectively suggest that LAR-RPTP clustering for synaptogenesis is modulated by a complex synapse-organizing protein network. | - |
dc.language | English | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.title | LAR-RPTP Clustering Is Modulated by Competitive Binding between Synaptic Adhesion Partners and Heparan Sulfate | - |
dc.type | Article | - |
dc.identifier.wosid | 000412877900001 | - |
dc.identifier.scopusid | 2-s2.0-85032278275 | - |
dc.type.rims | ART | - |
dc.citation.volume | 10 | - |
dc.citation.beginningpage | 327 | - |
dc.citation.publicationname | FRONTIERS IN MOLECULAR NEUROSCIENCE | - |
dc.identifier.doi | 10.3389/fnmol.2017.00327 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Kim, Eunjoon | - |
dc.contributor.localauthor | Heo, Won Do | - |
dc.contributor.localauthor | Lee, Jie-Oh | - |
dc.contributor.localauthor | Kim, Ho Min | - |
dc.contributor.nonIdAuthor | Kim, Doyoun | - |
dc.contributor.nonIdAuthor | Ko, Jaewon | - |
dc.contributor.nonIdAuthor | Um, Ji Won | - |
dc.contributor.nonIdAuthor | Lee, Sung Bae | - |
dc.contributor.nonIdAuthor | Buck, Matthias | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | LAR-RPTPs | - |
dc.subject.keywordAuthor | postsynaptic ligand | - |
dc.subject.keywordAuthor | synaptic adhesion molecules | - |
dc.subject.keywordAuthor | higher-order clustering | - |
dc.subject.keywordAuthor | heparan sulfate | - |
dc.subject.keywordAuthor | crystal structure | - |
dc.subject.keywordPlus | DEPENDENT TRANSSYNAPTIC ADHESION | - |
dc.subject.keywordPlus | PROTEIN-TYROSINE-PHOSPHATASES | - |
dc.subject.keywordPlus | MIDLINE AXON GUIDANCE | - |
dc.subject.keywordPlus | PTP-SIGMA | - |
dc.subject.keywordPlus | STRUCTURAL BASIS | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | PROTEOGLYCANS | - |
dc.subject.keywordPlus | ARCHITECTURE | - |
dc.subject.keywordPlus | MOLECULE | - |
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