Distinct Roles of Parvalbumin- and Somatostatin-Expressing Interneurons in Working Memory

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Inhibitory interneurons are thought to play crucial roles in diverse brain functions. However, roles of different inhibitory interneuron subtypes in working memory remain unclear. We found distinct activity patterns and stimulation effects of two major interneuron subtypes, parvalbumin (PV)- and somatostatin (SOM)-expressing interneurons, in the medial prefrontal cortex of mice performing a spatial working memory task. PV interneurons showed weak target-dependent delay-period activity and were strongly inhibited by reward. By contrast, SOM interneurons showed strong target-dependent delay-period activity, and only a subtype of them was inhibited by reward. Furthermore, optogenetic stimulation of PV and SOM interneurons preferentially suppressed discharges of putative pyramidal cells and interneurons, respectively. These results indicate different contributions of PV and SOM interneurons to prefrontal cortical circuit dynamics underlying working memory.
Publisher
CELL PRESS
Issue Date
2016-11
Language
English
Article Type
Article
Keywords

DELAYED ALTERNATION PERFORMANCE; PREFRONTAL CORTEX; CORTICAL MICROCIRCUIT; UNIT-ACTIVITY; INHIBITION; SUBTYPES; NEURONS; CELLS; MODEL; TASK

Citation

NEURON, v.92, no.4, pp.902 - 915

ISSN
0896-6273
DOI
10.1016/j.neuron.2016.09.023
URI
http://hdl.handle.net/10203/218310
Appears in Collection
BS-Journal Papers(저널논문)
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