Cell type-specific long-range connections of basal forebrain circuit

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The basal forebrain (BF) plays key roles in multiple brain functions, including sleep-wake regulation, attention, and learning/memory, but the long-range connections mediating these functions remain poorly characterized. Here we performed whole-brain mapping of both inputs and outputs of four BF cell types - cholinergic, glutamatergic, and parvalbumin-positive (PV+) and somatostatin-positive (SOM+) GABAergic neurons - in the mouse brain. Using rabies virus mediated monosynaptic retrograde tracing to label the inputs and adeno-associated virus to trace axonal projections, we identified numerous brain areas connected to the BF. The inputs to different cell types were qualitatively similar, but the output projections showed marked differences. The connections to glutamatergic and SOM+ neurons were strongly reciprocal, while those to cholinergic and PV+ neurons were more unidirectional. These results reveal the long-range wiring diagram of the BF circuit with highly convergent inputs and divergent outputs and point to both functional commonality and specialization of different BF cell types
Publisher
ELIFE SCIENCES PUBLICATIONS LTD
Issue Date
2016-09
Language
English
Article Type
Article
Keywords

SUBSTANTIA INNOMINATA; CHOLINERGIC NEURONS; NUCLEUS BASALIS; PROJECTION NEURONS; GABAERGIC NEURONS; DOPAMINE NEURONS; BRAIN-STEM; INPUTS; RAT; ACETYLCHOLINE

Citation

ELIFE, v.5

ISSN
2050-084X
DOI
10.7554/eLife.13214
URI
http://hdl.handle.net/10203/213882
Appears in Collection
BS-Journal Papers(저널논문)
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