Characterization of lipid-rich plaques using spectroscopic optical coherence tomography

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Intravascular optical coherence tomography (IV-OCT) is a high-resolution imaging method used to visualize the internal structures of walls of coronary arteries in vivo. However, accurate characterization of atherosclerotic plaques with gray-scale IV-OCT images is often limited by various intrinsic artifacts. In this study, we present an algorithm for characterizing lipid-rich plaques with a spectroscopic OCT technique based on a Gaussian center of mass (GCOM) metric. The GCOM metric, which reflects the absorbance properties of lipids, was validated using a lipid phantom. In addition, the proposed characterization method was successfully demonstrated in vivo using an atherosclerotic rabbit model and was found to have a sensitivity and specificity of 94.3% and 76.7% for lipid classification, respectively. (C) 2016 Society of Photo-Optical Instrumentation Engineers (SPIE
Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
Issue Date
2016-07
Language
English
Article Type
Article
Citation

JOURNAL OF BIOMEDICAL OPTICS, v.21, no.7

ISSN
1083-3668
DOI
10.1117/1.JBO.21.7.075004
URI
http://hdl.handle.net/10203/213089
Appears in Collection
ME-Journal Papers(저널논문)
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