Characterization of lipid-rich plaques using spectroscopic optical coherence tomography

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dc.contributor.authorNam, Hyeong Sooko
dc.contributor.authorSong, Joon Wooko
dc.contributor.authorJang, Sun Jooko
dc.contributor.authorLee, Jae Joongko
dc.contributor.authorOh, Wang-Yuhlko
dc.contributor.authorKim, Jin Wonko
dc.contributor.authorYoo, Hongkiko
dc.date.accessioned2016-10-04T07:20:52Z-
dc.date.available2016-10-04T07:20:52Z-
dc.date.created2016-09-21-
dc.date.created2016-09-21-
dc.date.created2016-09-21-
dc.date.issued2016-07-
dc.identifier.citationJOURNAL OF BIOMEDICAL OPTICS, v.21, no.7-
dc.identifier.issn1083-3668-
dc.identifier.urihttp://hdl.handle.net/10203/213089-
dc.description.abstractIntravascular optical coherence tomography (IV-OCT) is a high-resolution imaging method used to visualize the internal structures of walls of coronary arteries in vivo. However, accurate characterization of atherosclerotic plaques with gray-scale IV-OCT images is often limited by various intrinsic artifacts. In this study, we present an algorithm for characterizing lipid-rich plaques with a spectroscopic OCT technique based on a Gaussian center of mass (GCOM) metric. The GCOM metric, which reflects the absorbance properties of lipids, was validated using a lipid phantom. In addition, the proposed characterization method was successfully demonstrated in vivo using an atherosclerotic rabbit model and was found to have a sensitivity and specificity of 94.3% and 76.7% for lipid classification, respectively. (C) 2016 Society of Photo-Optical Instrumentation Engineers (SPIE-
dc.languageEnglish-
dc.publisherSPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS-
dc.titleCharacterization of lipid-rich plaques using spectroscopic optical coherence tomography-
dc.typeArticle-
dc.identifier.wosid000381917800025-
dc.identifier.scopusid2-s2.0-84978971676-
dc.type.rimsART-
dc.citation.volume21-
dc.citation.issue7-
dc.citation.publicationnameJOURNAL OF BIOMEDICAL OPTICS-
dc.identifier.doi10.1117/1.JBO.21.7.075004-
dc.contributor.localauthorOh, Wang-Yuhl-
dc.contributor.localauthorYoo, Hongki-
dc.contributor.nonIdAuthorNam, Hyeong Soo-
dc.contributor.nonIdAuthorSong, Joon Woo-
dc.contributor.nonIdAuthorLee, Jae Joong-
dc.contributor.nonIdAuthorKim, Jin Won-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthoroptical coherence tomography-
dc.subject.keywordAuthorlipid-rich plaque-
dc.subject.keywordAuthorspectroscopic optical coherence tomography-
dc.subject.keywordAuthortissue characterization-
dc.subject.keywordPlusNEAR-INFRARED SPECTROSCOPY-
dc.subject.keywordPlusBLOOD-OXYGEN SATURATION-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlusATHEROSCLEROTIC PLAQUES-
dc.subject.keywordPlusSCATTERING-
dc.subject.keywordPlusABSORPTION-
dc.subject.keywordPlusDERMATOLOGY-
dc.subject.keywordPlusMECHANISMS-
dc.subject.keywordPlusMICROSCOPY-
dc.subject.keywordPlusDISEASE-
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