Network of hypothalamic neurons that control appetite

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The central nervous system (CNS) controls food intake and energy expenditure via tight coordinations between multiple neuronal populations. Specifically, two distinct neuronal populations exist in the arcuate nucleus of hypothalamus (ARH): the anorexigenic (appetite-suppressing) pro-opiomelanocortin (POMC) neurons and the orexigenic (appetite-increasing) neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons. The coordinated regulation of neuronal circuit involving these neurons is essential in properly maintaining energy balance, and any disturbance therein may result in hyperphagia/obesity or hypophagia/starvation. Thus, adequate knowledge of the POMC and NPY/AgRP neuron physiology is mandatory to understand the pathophysiology of obesity and related metabolic diseases. This review will discuss the history and recent updates on the POMC and NPY/AgRP neuronal circuits, as well as the general anorexigenic and orexigenic circuits in the CNS.
Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Issue Date
2015-04
Language
English
Article Type
Review
Keywords

ARCUATE PROOPIOMELANOCORTIN NEURONS; ENERGY HOMEOSTASIS; POMC NEURONS; PARAVENTRICULAR NUCLEUS; PARABRACHIAL NUCLEUS; GLUCOSE-HOMEOSTASIS; REGULATE ENERGY; AGRP NEURONS; MELANOCORTIN PATHWAYS; FEEDING-BEHAVIOR

Citation

BMB REPORTS, v.48, no.4, pp.229 - 233

ISSN
1976-6696
DOI
10.5483/BMBRep.2015.48.4.272
URI
http://hdl.handle.net/10203/199479
Appears in Collection
BS-Journal Papers(저널논문)
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