DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Young-Gyun | ko |
dc.contributor.author | Choi, Jee Hyun | ko |
dc.contributor.author | Lee, Chungki | ko |
dc.contributor.author | Kim, Sehyun | ko |
dc.contributor.author | Kim, Young Soo | ko |
dc.contributor.author | Chang, Ki-Young | ko |
dc.contributor.author | Paek, Sun Ha | ko |
dc.contributor.author | Kim, Daesoo | ko |
dc.date.accessioned | 2015-04-07T05:16:51Z | - |
dc.date.available | 2015-04-07T05:16:51Z | - |
dc.date.created | 2015-02-26 | - |
dc.date.created | 2015-02-26 | - |
dc.date.created | 2015-02-26 | - |
dc.date.issued | 2015-01 | - |
dc.identifier.citation | MOLECULAR BRAIN, v.8 | - |
dc.identifier.issn | 1756-6606 | - |
dc.identifier.uri | http://hdl.handle.net/10203/195325 | - |
dc.description.abstract | Background: Identifying a neural circuit mechanism that is differentially involved in tremor would aid in the diagnosis and cure of such cases. Here, we demonstrate that tremor-related cortical potential (TRCP) is differentially expressed in two different mouse models of tremor. Results: Hybrid tremor analysis of harmaline-induced and genetic tremor in mice revealed that two authentic tremor frequencies for each type of tremor were conserved and showed an opposite dependence on CaV3.1 T-type Ca2+ channels. Electroencephalogram recordings revealed that a1(-/-); a1G(-/-) mice double-null for the GABA receptor a1 subunit (Gabra1) and CaV3.1 T-type Ca2+ channels (Cacna1g), in which the tremor caused by the absence of Gabra1 is potentiated by the absence of Cacna1g, showed a coherent TRCP that exhibited an onset that preceded the initiation of behavioral tremor by 3 ms. However, harmaline-induced tremor, which is known to be abolished by a1G(-/-), showed no TRCP. Conclusions: Our results demonstrate that the a1(-/-); a1G(-/-) double-knockout tremor model is useful for studying cortical mechanisms of tremor. | - |
dc.language | English | - |
dc.publisher | BIOMED CENTRAL LTD | - |
dc.title | Heterogeneity of tremor mechanisms assessed by tremor-related cortical potential in mice | - |
dc.type | Article | - |
dc.identifier.wosid | 000348233900001 | - |
dc.identifier.scopusid | 2-s2.0-85017331046 | - |
dc.type.rims | ART | - |
dc.citation.volume | 8 | - |
dc.citation.publicationname | MOLECULAR BRAIN | - |
dc.identifier.doi | 10.1186/s13041-015-0093-2 | - |
dc.contributor.localauthor | Park, Young-Gyun | - |
dc.contributor.localauthor | Kim, Daesoo | - |
dc.contributor.nonIdAuthor | Choi, Jee Hyun | - |
dc.contributor.nonIdAuthor | Lee, Chungki | - |
dc.contributor.nonIdAuthor | Paek, Sun Ha | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Tremor mechanism | - |
dc.subject.keywordAuthor | Cortical rhythm | - |
dc.subject.keywordAuthor | Harmaline | - |
dc.subject.keywordAuthor | T-type Ca2+ channels | - |
dc.subject.keywordPlus | HARMALINE-INDUCED TREMOR | - |
dc.subject.keywordPlus | MOTOR COORDINATION | - |
dc.subject.keywordPlus | INFERIOR OLIVE | - |
dc.subject.keywordPlus | CA2+ CHANNELS | - |
dc.subject.keywordPlus | PATHOPHYSIOLOGY | - |
dc.subject.keywordPlus | DISORDER | - |
dc.subject.keywordPlus | CA(V)3.1 | - |
dc.subject.keywordPlus | NEURONS | - |
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