Deoxyribozyme-loaded nano-graphene oxide for simultaneous sensing and silencing of the hepatitis C virus gene in liver cells

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The multifunctional DNAzyme (Dz) delivery system is developed based on nano-sized graphene oxide (nGO) for simultaneous detection and knockdown of the target gene. The Dz/nGO complex system allowed convenient monitoring of HCV mRNA in living cells and silencing of the HCV gene expression by Dz-mediated catalytic cleavage concurrently.
Publisher
ROYAL SOC CHEMISTRY
Issue Date
2013-10
Language
English
Article Type
Article
Keywords

DNA ENZYMES; DELIVERY; DNAZYME; RNA; NANOPARTICLES; REPLICATION; COMPLEX; DRUGS

Citation

CHEMICAL COMMUNICATIONS, v.49, no.74, pp.8241 - 8243

ISSN
1359-7345
DOI
10.1039/c3cc43368d
URI
http://hdl.handle.net/10203/193115
Appears in Collection
CH-Journal Papers(저널논문)
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