Current status of polymeric gene delivery systems

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Gene therapy provides great opportunities for treating diseases from genetic disorders, infections and cancer. To achieve successful gene therapy, development of proper gene delivery systems could be one of the most important factors. Several non-viral gene transfer methods have been developed to overcome the safety problems of their viral counterpart. Polymer-based non-viral gene carriers have been used due to their merits in safety including the avoidance of potential immunogenecity and toxicity, the possibility of repeated administration, and the ease of the establishment of good manufacturing practice (GMP). A wide range of polymeric vectors have been utilized to deliver therapeutic genes in vivo. The modification of polymeric vectors has also shown successful improvements in achieving target-specific delivery and in promoting intracellular gene transfer efficiency. Various systemic and cellular barriers, including serum proteins in blood stream, cell membrane, endosomal compartment and nuclear membrane, were successfully circumvented by designing polymer carriers having a smart molecular structure. This review explores the recent development of polymeric gene carriers and presents the future directions for the application of the polymer-based gene delivery systems in gene therapy. (c) 2006 Elsevier B.V. All rights reserved.
Publisher
ELSEVIER SCIENCE BV
Issue Date
2006-07
Language
English
Article Type
Review
Keywords

POLY-L-LYSINE; BIODEGRADABLE TRIBLOCK COPOLYMER; WATER-SOLUBLE LIPOPOLYMER; INDUCED PHASE-SEPARATION; PLASMID DNA DELIVERY; PLGA-PEG-PLGA; IN-VIVO; MOLECULAR-WEIGHT; COMPLEX MICELLES; BLOCK-COPOLYMERS

Citation

ADVANCED DRUG DELIVERY REVIEWS, v.58, no.4, pp.467 - 486

ISSN
0169-409X
DOI
10.1016/j.addr.2006.03.007
URI
http://hdl.handle.net/10203/12343
Appears in Collection
BS-Journal Papers(저널논문)
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