DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bae, Ki Hyun | ko |
dc.contributor.author | Park, Mihyun | ko |
dc.contributor.author | Do, Min Jae | ko |
dc.contributor.author | Lee, Nohyun | ko |
dc.contributor.author | Ryu, Ji Hyun | ko |
dc.contributor.author | Kim, Gun Woo | ko |
dc.contributor.author | Kim, CheolGi | ko |
dc.contributor.author | Park, Tae Gwan | ko |
dc.contributor.author | Hyeon, Taeghwan | ko |
dc.date.accessioned | 2013-03-13T01:50:54Z | - |
dc.date.available | 2013-03-13T01:50:54Z | - |
dc.date.created | 2012-08-21 | - |
dc.date.created | 2012-08-21 | - |
dc.date.issued | 2012-06 | - |
dc.identifier.citation | ACS NANO, v.6, no.6, pp.5266 - 5273 | - |
dc.identifier.issn | 1936-0851 | - |
dc.identifier.uri | http://hdl.handle.net/10203/104163 | - |
dc.description.abstract | Magnetic nanoparticles have gained significant attention as a therapeutic agent for cancer treatment. Herein, we developed chitosan oligosaccharide-stabilized ferrimagnetic iron oxide nanocubes (Chito-FIONs) as an effective heat nanomediator for cancer hyperthermia. Dynamic light scattering and transmission electron microscopic analyses revealed that Chito-FIONs were composed of multiple 30-nm-sized FIONs encapsulated by a chitosan polymer shell. Multiple FIONs in an interior increased the total magnetic moments, which leads to localized accumulation under an applied magnetic field. Chito-FIONs also exhibited superior magnetic heating ability with a high specific loss power value (2614 W/g) compared with commercial superparamagnetic Feridex nanoparticles (83 W/g). The magnetically guided Chito-FIONs successfully eradicated target cancer cells through caspase-mediated apoptosis. Furthermore, Chito-FIONs showed excellent antitumor efficacy on an animal tumor model without any severe toxicity. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | MRI CONTRAST | - |
dc.subject | NANOPARTICLES | - |
dc.subject | THERAPY | - |
dc.subject | FUNCTIONALIZATION | - |
dc.subject | BIOMEDICINE | - |
dc.subject | MOLECULES | - |
dc.subject | DELIVERY | - |
dc.subject | RELEASE | - |
dc.subject | BILAYER | - |
dc.subject | CELLS | - |
dc.title | Chitosan Oligosaccharide-Stabilized Ferrimagnetic Iron Oxide Nanocubes for Magnetically Modulated Cancer Hyperthermia | - |
dc.type | Article | - |
dc.identifier.wosid | 000305661300078 | - |
dc.identifier.scopusid | 2-s2.0-84862860615 | - |
dc.type.rims | ART | - |
dc.citation.volume | 6 | - |
dc.citation.issue | 6 | - |
dc.citation.beginningpage | 5266 | - |
dc.citation.endingpage | 5273 | - |
dc.citation.publicationname | ACS NANO | - |
dc.identifier.doi | 10.1021/nn301046w | - |
dc.contributor.localauthor | Park, Tae Gwan | - |
dc.contributor.nonIdAuthor | Park, Mihyun | - |
dc.contributor.nonIdAuthor | Do, Min Jae | - |
dc.contributor.nonIdAuthor | Lee, Nohyun | - |
dc.contributor.nonIdAuthor | Kim, Gun Woo | - |
dc.contributor.nonIdAuthor | Kim, CheolGi | - |
dc.contributor.nonIdAuthor | Hyeon, Taeghwan | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | chitosan | - |
dc.subject.keywordAuthor | magnetite | - |
dc.subject.keywordAuthor | magnetic modulation | - |
dc.subject.keywordAuthor | nanocube | - |
dc.subject.keywordAuthor | cancer therapy | - |
dc.subject.keywordAuthor | hyperthermia | - |
dc.subject.keywordPlus | MRI CONTRAST | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | FUNCTIONALIZATION | - |
dc.subject.keywordPlus | BIOMEDICINE | - |
dc.subject.keywordPlus | MOLECULES | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | BILAYER | - |
dc.subject.keywordPlus | CELLS | - |
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