Inositol polyphosphate multikinase: An emerging player for the central action of AMP-activated protein kinase

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AMP-activated protein kinase (AMPK) is an essential enzyme indispensable for energy sensing and metabolic homeostasis at both the cellular and whole-body levels. Phosphorylation of AMPK, a key step for its activation, is known to be regulated by upstream kinases such as liver kinase B1 (LKB1) and calmodulin-dependent protein kinase kinase-beta (CaMKK beta). Recent evidence shows that inositol polyphosphate multikinase (IPMK), which possesses both inositol phosphate kinase and lipid inositol kinase activities, can physiologically regulate AMPK signaling in cultured cells and in the arcuate nucleus. IPMK-mediated regulation of AMPK occurs through the dynamic protein interactions of IPMK with AMPK in response to glucose availability. Here we review and discuss a novel role for the hypothalamic IPMK signaling in the control of AMPK and central energy homeostasis. (C) 2012 Elsevier Inc. All rights reserved.
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Issue Date
2012-04
Language
English
Article Type
Review
Keywords

FOOD-INTAKE; METABOLISM; MUTATIONS; NUCLEUS; SIGNALS

Citation

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.421, no.1, pp.1 - 3

ISSN
0006-291X
DOI
10.1016/j.bbrc.2012.04.010
URI
http://hdl.handle.net/10203/102609
Appears in Collection
BS-Journal Papers(저널논문)
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