Panniculitis generally indicates a group of diseases whose hallmark is fibrous thickening and chronic inflammation
of subcutaneous fat. Various factors seem to induce a similar pathological histology, and morphological differences
can be found among the patients diagnosed with the same disease. Paraneoplastic causes account for 3∼10% of the
cases of panniculitis. The commonest causes of cancer associated panniculitis are hematological malignancies and
mostly lymphomas. In this case, we confirmed acute myeloid leukemia by a blood test and bone marrow
examination, and with considering the clinical aspects and pathological findings of the skin lesion, and we finally
diagnosed the patient as having panniculitis, which seems to be related with acute myeloid leukemia. The obvious
clinical symptoms or pathophysiological features of this rare type of panniculitis are not yet fully known, and so
making the differential diagnosis is needed to distinguish this malady from erythema nodosum, erythema induratum
and various connective tissue disorders with accompanying erythematous subcutaneous nodules. We diagnosed this
very rare and interesting case of paraneoplastic panniculitis that seemed to be generated from acute myeloid
leukemia. We report here on this case and we review the relevant literature.