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College of Life Science and Bioengineering(생명과학기술대학)Dept. of Biological Sciences(생명과학과)BS-Journal Papers(저널논문)

Human papillomavirus type 16 E6 protein inhibits DNA fragmentation via interaction with DNA fragmentation factor 40

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dc.contributor.authorJong, Jae Eunko
dc.contributor.authorJeong, Kwi Wanko
dc.contributor.authorShin, Hyokyungko
dc.contributor.authorHwang, Lee Rangko
dc.contributor.authorLee, Daeyoupko
dc.contributor.authorSeo, Taegunko
dc.date.accessioned2013-03-12T04:33:03Z-
dc.date.available2013-03-12T04:33:03Z-
dc.date.created2012-09-26-
dc.date.created2012-09-26-
dc.date.issued2012-11-
dc.identifier.citationCANCER LETTERS, v.324, no.1, pp.109 - 117-
dc.identifier.issn0304-3835-
dc.identifier.urihttp://hdl.handle.net/10203/101343-
dc.description.abstractThe E6 oncoprotein of human papillomavirus (HPV) is critical in cervical cancer development. Using the yeast two-hybrid assay, we showed that HPV-16 E6 (16E6) interacts with one of the DNA fragmentation factors (DFFs), DFF40, which mediates DNA degradation during apoptosis. Furthermore, 16E6 interacts with DFF40 through its zinc finger motif 2 and a bridge section linking the two zinc finger motifs. DNA fragmentation assays disclosed that 16E6 binding to DFF40 leads to blockage of DNA cleavage. Our data collectively suggest that suppression of DNA fragmentation through 16E6-DFF40 interaction is a central event promoting tumorigenesis. (C) 2012 Elsevier Ireland Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherELSEVIER IRELAND LTD-
dc.subjectCASPASE-ACTIVATED DNASE-
dc.subjectCELL-DEATH-
dc.subjectHPV E6-
dc.subjectAPOPTOSIS-
dc.subjectONCOPROTEIN-
dc.subjectCANCER-
dc.subjectDEGRADATION-
dc.subjectEXPRESSION-
dc.subjectIDENTIFICATION-
dc.subjectBINDS-
dc.titleHuman papillomavirus type 16 E6 protein inhibits DNA fragmentation via interaction with DNA fragmentation factor 40-
dc.typeArticle-
dc.identifier.wosid000307420200012-
dc.identifier.scopusid2-s2.0-84864059305-
dc.type.rimsART-
dc.citation.volume324-
dc.citation.issue1-
dc.citation.beginningpage109-
dc.citation.endingpage117-
dc.citation.publicationnameCANCER LETTERS-
dc.identifier.doi10.1016/j.canlet.2012.05.010-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorLee, Daeyoup-
dc.contributor.nonIdAuthorJong, Jae Eun-
dc.contributor.nonIdAuthorJeong, Kwi Wan-
dc.contributor.nonIdAuthorShin, Hyokyung-
dc.contributor.nonIdAuthorHwang, Lee Rang-
dc.contributor.nonIdAuthorSeo, Taegun-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorHuman papillomavirus-16-
dc.subject.keywordAuthorE6 protein-
dc.subject.keywordAuthorDNA fragmentation factor-
dc.subject.keywordPlusCASPASE-ACTIVATED DNASE-
dc.subject.keywordPlusCELL-DEATH-
dc.subject.keywordPlusHPV E6-
dc.subject.keywordPlusAPOPTOSIS-
dc.subject.keywordPlusONCOPROTEIN-
dc.subject.keywordPlusCANCER-
dc.subject.keywordPlusDEGRADATION-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusIDENTIFICATION-
dc.subject.keywordPlusBINDS-
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