Base pair opening kinetics and dynamics in the DNA duplexes that specifically recognized by very short patch repair protein (Vsr)

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In Escherichia coli, the very short patch (VSP) repair system is a major pathway for removal of T G mismatches in Dcm target sequences In the VSP repair pathway, the very short patch repair (Vsr) endonuclease selectively recognizes a T G mismatch in Dcm target sequences and hydrolyzes the 5'-phosphate group of the mismatched thymine The hydrogen exchange NMR studies here revealed that the T5 G18 mismatch in the Dcm target sequence significantly stabilizes own base pair but destabilizes the two neighboring G4 C19 and A6 T17 base pairs compare to other TG mismatches These unusual patterns of base pair stability in the Dcm target sequence can explain how the Vsr endonuclease specifically recognizes the mismatched Dcm target sequence and intercalates into the DNA. (C) 2010 Elsevier Inc. All rights reserved
Publisher
ELSEVIER SCIENCE INC
Issue Date
2010-09
Language
English
Article Type
Article
Keywords

IMINO PROTON-EXCHANGE; ESCHERICHIA-COLI; MISMATCH ENDONUCLEASE; MECHANISM; CLEAVAGE; BINDING; COMPLEX; RNA

Citation

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, v.501, no.2, pp.201 - 206

ISSN
0003-9861
DOI
10.1016/j.abb.2010.06.005
URI
http://hdl.handle.net/10203/98651
Appears in Collection
CH-Journal Papers(저널논문)
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