A new structural class of S-adenosylhomocysteine hydrolase inhibitors

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dc.contributor.authorKim, Byung Gyuko
dc.contributor.authorChun, Tae Gyuko
dc.contributor.authorLee, Hee Yoonko
dc.contributor.authorSnapper, Marc L.ko
dc.date.accessioned2013-03-11T06:19:18Z-
dc.date.available2013-03-11T06:19:18Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2009-09-
dc.identifier.citationBIOORGANIC MEDICINAL CHEMISTRY, v.17, no.18, pp.6707 - 6714-
dc.identifier.issn0968-0896-
dc.identifier.urihttp://hdl.handle.net/10203/98491-
dc.description.abstractEffective inhibitors of S-adenosylhomocysteine hydrolase hold promise towards becoming useful therapeutic agents. Since most efforts have focused on the development of nucleoside analog inhibitors, issues regarding bioavailability and selectivity have been major challenges. Considering the marine sponge metabolite ilimaquinone was found to be a competitive inhibitor of S-adenosylhomocysteine hydrolase, new opportunities for developing selective new inhibitors of this enzyme have become available. Based on the activities of various hybrid analogs, SAR studies, pharmacophore modeling, and computer docking studies have lead to a predictive understanding of ilimaquinone's S-adenosylhomocysteine hydrolase inhibitory activities. These studies have allowed for the design and preparation of simplified structural variants possessing new furanoside bioisosteres with 100-fold greater inhibitory activities than that of the natural product. (C) 2009 Published by Elsevier Ltd.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectL-HOMOCYSTEINE HYDROLASE-
dc.subjectPOTENT INHIBITORS-
dc.subjectMARINE SPONGE-
dc.subjectANALOGS-
dc.subjectAVAROL-
dc.subjectILIMAQUINONE-
dc.subjectVIRUS-
dc.subject(-)-ILIMAQUINONE-
dc.subjectILLIMAQUINONE-
dc.subjectINACTIVATION-
dc.titleA new structural class of S-adenosylhomocysteine hydrolase inhibitors-
dc.typeArticle-
dc.identifier.wosid000269399700025-
dc.identifier.scopusid2-s2.0-69249106092-
dc.type.rimsART-
dc.citation.volume17-
dc.citation.issue18-
dc.citation.beginningpage6707-
dc.citation.endingpage6714-
dc.citation.publicationnameBIOORGANIC MEDICINAL CHEMISTRY-
dc.identifier.doi10.1016/j.bmc.2009.07.061-
dc.contributor.localauthorLee, Hee Yoon-
dc.contributor.nonIdAuthorKim, Byung Gyu-
dc.contributor.nonIdAuthorSnapper, Marc L.-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorIlimaquinone-
dc.subject.keywordAuthorS-Adenosylhomocysteine hydrolase-
dc.subject.keywordAuthorInhibitor-
dc.subject.keywordAuthorPharmacophore modeling-
dc.subject.keywordPlusL-HOMOCYSTEINE HYDROLASE-
dc.subject.keywordPlusPOTENT INHIBITORS-
dc.subject.keywordPlusMARINE SPONGE-
dc.subject.keywordPlusANALOGS-
dc.subject.keywordPlusAVAROL-
dc.subject.keywordPlusILIMAQUINONE-
dc.subject.keywordPlusVIRUS-
dc.subject.keywordPlus(-)-ILIMAQUINONE-
dc.subject.keywordPlusILLIMAQUINONE-
dc.subject.keywordPlusINACTIVATION-
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