DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jiang, Xiaoyu | ko |
dc.contributor.author | Lu, Xiaoqing | ko |
dc.contributor.author | McNamara, George | ko |
dc.contributor.author | Liu, Xiaofei | ko |
dc.contributor.author | Cubedo, Elena | ko |
dc.contributor.author | Sarosiek, Kristopher A. | ko |
dc.contributor.author | Sanchez-Garcia, Isidro | ko |
dc.contributor.author | Helfman, David M | ko |
dc.contributor.author | Lossos, Izidore S. | ko |
dc.date.accessioned | 2013-03-09T20:12:01Z | - |
dc.date.available | 2013-03-09T20:12:01Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2010-12 | - |
dc.identifier.citation | BLOOD, v.116, no.24, pp.5217 - 5227 | - |
dc.identifier.issn | 0006-4971 | - |
dc.identifier.uri | http://hdl.handle.net/10203/97363 | - |
dc.description.abstract | HGAL is a germinal center (GC)-specific gene that negatively regulates lymphocyte motility and whose expression predicts improved survival of patients with diffuse large B-cell lymphoma (DLBCL) and classical Hodgkin lymphoma (cHL). We demonstrate that HGAL serves as a regulator of the RhoA signaling pathway. HGAL enhances activation of RhoA and its down-stream effectors by a novel mechanism - direct binding to the catalytic DH-domain of the RhoA-specific guanine nucleotide exchange factors (Rho-GEFs) PDZ-RhoGEF and LARG that stimulate the GDP-GTP exchange rate of RhoA. We delineate the structural domain of HGAL that mediates its interaction with the PDZ-RhoGEF protein. These observations reveal a novel molecular mechanism underlying the inhibitory effects of GC-specific HGAL protein on the motility of GC-derived lymphoma cells. This mechanism may underlie the limited dissemination and better outcome of patients with HGAL-expressing DLBCL and cHL. (Blood. 2010;116(24):5217-5227) | - |
dc.language | English | - |
dc.publisher | AMER SOC HEMATOLOGY | - |
dc.subject | NUCLEOTIDE-EXCHANGE FACTORS | - |
dc.subject | REGULATORY LIGHT-CHAIN | - |
dc.subject | PDZ-RHOGEF | - |
dc.subject | MYOSIN-II | - |
dc.subject | B-CELLS | - |
dc.subject | HODGKIN LYMPHOMA | - |
dc.subject | EXPRESSION | - |
dc.subject | MIGRATION | - |
dc.subject | KINASE | - |
dc.subject | SURVIVAL | - |
dc.title | HGAL, a germinal center specific protein, decreases lymphoma cell motility by modulation of the RhoA signaling pathway | - |
dc.type | Article | - |
dc.identifier.wosid | 000285141200020 | - |
dc.identifier.scopusid | 2-s2.0-78650071942 | - |
dc.type.rims | ART | - |
dc.citation.volume | 116 | - |
dc.citation.issue | 24 | - |
dc.citation.beginningpage | 5217 | - |
dc.citation.endingpage | 5227 | - |
dc.citation.publicationname | BLOOD | - |
dc.identifier.doi | 10.1182/blood-2010-04-281568 | - |
dc.contributor.localauthor | Helfman, David M | - |
dc.contributor.nonIdAuthor | Jiang, Xiaoyu | - |
dc.contributor.nonIdAuthor | Lu, Xiaoqing | - |
dc.contributor.nonIdAuthor | McNamara, George | - |
dc.contributor.nonIdAuthor | Liu, Xiaofei | - |
dc.contributor.nonIdAuthor | Cubedo, Elena | - |
dc.contributor.nonIdAuthor | Sarosiek, Kristopher A. | - |
dc.contributor.nonIdAuthor | Sanchez-Garcia, Isidro | - |
dc.contributor.nonIdAuthor | Lossos, Izidore S. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | NUCLEOTIDE-EXCHANGE FACTORS | - |
dc.subject.keywordPlus | REGULATORY LIGHT-CHAIN | - |
dc.subject.keywordPlus | PDZ-RHOGEF | - |
dc.subject.keywordPlus | MYOSIN-II | - |
dc.subject.keywordPlus | B-CELLS | - |
dc.subject.keywordPlus | HODGKIN LYMPHOMA | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | SURVIVAL | - |
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