Effect of applying modes of the polymer microneedle-roller on the permeation of L-ascorbic acid in rats

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Despite the advantages of drug delivery through skin, transdermal drug delivery is only used with a small subset of drugs because most compounds cannot cross the skin at therapeutically useful rates. Recently, a new concept known as microneedle was introduced and could be used to pierce effectively to deliver drugs using micron-sized needles in a minimally invasive and painless manner. In this study, the polymer microneedle-roller was fabricated so that it can be applied into the permeation Of L-ascorbic acid. Moreover, a recent publication suggested the possibility of ascorbic acid 2-phosphate as a hair restorer; hence, this study was carried out to check the effect Of L-ascorbic acid itself on the hair growing rate in rats according to the presence of various application frequencies of the polymer microneedle-roller. When the polymer microneedle-roller was applied nine times with four directions into rat's shaved skin, the permeation Of L-ascorbic acid increased by 10.54-fold compared to that of the absence of the polymer microneedle-roller. The histological examination revealed that the skin pretreated with various application frequencies of the polymer microneedle-roller had more transport pathways. The faster hair growing phenomenon was observed in the presence of polymer microneedle-roller compared to the absence of the polymer microneedle-roller.
Publisher
Informa Healthcare
Issue Date
2010-01
Language
English
Article Type
Article
Keywords

TRANSDERMAL DRUG-DELIVERY; TOPICAL VITAMIN-C; GENE DELIVERY; SKIN; IMMUNIZATION; ANTIOXIDANTS; SYSTEMS; ARRAY

Citation

JOURNAL OF DRUG TARGETING, v.18, no.1, pp.15 - 20

ISSN
1061-186X
DOI
10.3109/10611860903115274
URI
http://hdl.handle.net/10203/96617
Appears in Collection
ME-Journal Papers(저널논문)
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