DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Soo-Hyeon | ko |
dc.contributor.author | Mok, Hye-Jung | ko |
dc.contributor.author | Lee, Yu-Han | ko |
dc.contributor.author | Park, Tae-Gwan | ko |
dc.date.accessioned | 2013-03-09T08:21:35Z | - |
dc.date.available | 2013-03-09T08:21:35Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2011-05 | - |
dc.identifier.citation | JOURNAL OF CONTROLLED RELEASE, v.152, no.1, pp.152 - 158 | - |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.uri | http://hdl.handle.net/10203/95852 | - |
dc.description.abstract | Biodegradable poly(D,L-lactic-co-glycolic acid) (PLGA) was conjugated to the 3' end of small interfering RNA (siRNA) via a disulfide bond to synthesize siRNA-PLGA hybrid conjugates. siRNA-PLGA conjugates were spontaneously self-assembled to form a spherical core/shell type micellar structure of similar to 20 nm in an aqueous environment, probably by hydrophobic interaction of PLGA blocks in the core surrounded by an siRNA shell layer. When linear polyethylenimine was added to the siRNA-PLGA micelles in aqueous solution, stable siRNA-PLGA/LPEI micelles with a size of similar to 30 nm were produced via ionic complexation between siRNA and LPEI in the outer shell. The cationic siRNA-PLGA/LPEI micelles showed superior intracellular uptake and enhanced gene silencing effect, compared to naked siRNA/LPEI complexes. The hybrid micelle structure based on siRNA and PLGA can be potentially used as an efficient siRNA delivery system for gene silencing. (C) 2010 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.publisher | Elsevier Science Bv | - |
dc.subject | POLYELECTROLYTE COMPLEX MICELLES | - |
dc.subject | BLOCK-COPOLYMER | - |
dc.subject | DELIVERY CARRIERS | - |
dc.subject | SYSTEMIC DELIVERY | - |
dc.subject | CELLULAR UPTAKE | - |
dc.subject | PLASMID DNA | - |
dc.subject | NANOPARTICLES | - |
dc.subject | RNA | - |
dc.subject | POLYMER | - |
dc.subject | ACID | - |
dc.title | Self-assembled siRNA-PLGA conjugate micelles for gene silencing | - |
dc.type | Article | - |
dc.identifier.wosid | 000292718200019 | - |
dc.identifier.scopusid | 2-s2.0-79958168461 | - |
dc.type.rims | ART | - |
dc.citation.volume | 152 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 152 | - |
dc.citation.endingpage | 158 | - |
dc.citation.publicationname | JOURNAL OF CONTROLLED RELEASE | - |
dc.contributor.localauthor | Park, Tae-Gwan | - |
dc.contributor.nonIdAuthor | Mok, Hye-Jung | - |
dc.contributor.nonIdAuthor | Lee, Yu-Han | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | siRNA | - |
dc.subject.keywordAuthor | PLGA | - |
dc.subject.keywordAuthor | Self-assembled micelles | - |
dc.subject.keywordAuthor | Linear polyethylenimine | - |
dc.subject.keywordAuthor | Target gene silencing | - |
dc.subject.keywordPlus | POLYELECTROLYTE COMPLEX MICELLES | - |
dc.subject.keywordPlus | BLOCK-COPOLYMER | - |
dc.subject.keywordPlus | DELIVERY CARRIERS | - |
dc.subject.keywordPlus | SYSTEMIC DELIVERY | - |
dc.subject.keywordPlus | CELLULAR UPTAKE | - |
dc.subject.keywordPlus | PLASMID DNA | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | RNA | - |
dc.subject.keywordPlus | POLYMER | - |
dc.subject.keywordPlus | ACID | - |
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