Gene Silencing by siRNA Microhydrogels via Polymeric Nanoscale Condensation
The first attempt to prepare biologically active siRNA-based microhydrogels is reported. The self-assembled microhydrogels were fabricated using sense/antisense complementary hybridization between single-stranded linear and Y-shaped trimeric siRNAs. The siRNA microhydrogels were condensed using a popular cationic polymer such as LPEI to form compact, stable siRNA/polymeric nanopartides that exhibited superb cellular uptake efficiency and gene silencing activity.
- Publisher
- AMER CHEMICAL SOC
- Issue Date
- 2011-09
- Language
- English
- Article Type
- Article
- Keywords
ATOMIC-FORCE MICROSCOPY; DOUBLE-STRANDED-RNA; DNA HYDROGEL; INTERFERENCE; DELIVERY; LONG; MOLECULE; SIZE; TOOL; AFM
- Citation
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.133, no.35, pp.13914 - 13917
- ISSN
- 0002-7863
- Appears in Collection
- BS-Journal Papers(저널논문)CH-Journal Papers(저널논문)
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