DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Seung Yong | ko |
dc.contributor.author | Lee, Yuhan | ko |
dc.contributor.author | Kim, Ju Eun | ko |
dc.contributor.author | Park, Tae Gwan | ko |
dc.contributor.author | Ahn, Cheol-Hee | ko |
dc.date.accessioned | 2013-03-08T17:16:26Z | - |
dc.date.available | 2013-03-08T17:16:26Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | JOURNAL OF MATERIALS CHEMISTRY, v.19, no.43, pp.8198 - 8201 | - |
dc.identifier.issn | 0959-9428 | - |
dc.identifier.uri | http://hdl.handle.net/10203/93711 | - |
dc.description.abstract | A thermogelling PEG-PPG-PEG triblock copolymer, Pluronic F127, was modified with diamines containing different numbers of secondary amino groups in order to produce a novel pH-sensitive gelling material. The degree of end group modification was over 95% without any noticeable multi-block formation. Modified F127 displayed a closed-loop sol-gel-sol transition in 16 wt% PBS solution and the loop was significantly shifted with pH depending on the nature of end-capping diamines. Temperature-and pH-sensitive phase transition was caused by a subtle change in hydrophilicity and hydrophobicity balance derived from the pK(a) values of the diamine groups at the distal PEG blocks. (1)H-NMR, GPC and dynamic mechanical analysis were employed for the characterization of modified F127 and its gelation behavior. | - |
dc.language | English | - |
dc.publisher | Royal Soc Chemistry | - |
dc.subject | DRUG-DELIVERY SYSTEMS | - |
dc.subject | AQUEOUS-SOLUTIONS | - |
dc.subject | HYDROGELS | - |
dc.subject | GELATION | - |
dc.subject | INTERFACES | - |
dc.subject | RHEOLOGY | - |
dc.subject | RELEASE | - |
dc.title | A novel pH-sensitive PEG-PPG-PEG copolymer displaying a closed-loop sol-gel-sol transition | - |
dc.type | Article | - |
dc.identifier.wosid | 000271191200022 | - |
dc.identifier.scopusid | 2-s2.0-70350712368 | - |
dc.type.rims | ART | - |
dc.citation.volume | 19 | - |
dc.citation.issue | 43 | - |
dc.citation.beginningpage | 8198 | - |
dc.citation.endingpage | 8201 | - |
dc.citation.publicationname | JOURNAL OF MATERIALS CHEMISTRY | - |
dc.identifier.doi | 10.1039/b912540j | - |
dc.contributor.localauthor | Park, Tae Gwan | - |
dc.contributor.nonIdAuthor | Lee, Seung Yong | - |
dc.contributor.nonIdAuthor | Kim, Ju Eun | - |
dc.contributor.nonIdAuthor | Ahn, Cheol-Hee | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | DRUG-DELIVERY SYSTEMS | - |
dc.subject.keywordPlus | AQUEOUS-SOLUTIONS | - |
dc.subject.keywordPlus | HYDROGELS | - |
dc.subject.keywordPlus | GELATION | - |
dc.subject.keywordPlus | INTERFACES | - |
dc.subject.keywordPlus | RHEOLOGY | - |
dc.subject.keywordPlus | RELEASE | - |
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