DC Field | Value | Language |
---|---|---|
dc.contributor.author | Im, SS | ko |
dc.contributor.author | Kim, JW | ko |
dc.contributor.author | Kim, TH | ko |
dc.contributor.author | Song, XL | ko |
dc.contributor.author | Kim, SY | ko |
dc.contributor.author | Kim, Il-Doo | ko |
dc.contributor.author | Ahn, YH | ko |
dc.date.accessioned | 2013-03-08T07:41:24Z | - |
dc.date.available | 2013-03-08T07:41:24Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2005-04 | - |
dc.identifier.citation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.37, pp.101 - 110 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | http://hdl.handle.net/10203/92499 | - |
dc.description.abstract | In the present study, we show that the expression of type 2 glucose transporter isoform (GLUT2) could be regulated by PPAR-gamma in the liver. Rosiglitazone, PPAR-gamma agonist, activated the GLUT2 mRNA level in the primary cultured hepatocytes and Alexander cells, when these cells were transfected with PPAR-gamma/RXR-alpha. We have localized the peroxisome proliferator response element in the mouse GLUT2 promoter by serial deletion studies and site-directed mutagenesis. Chromatin immunoprecipitation assay using ob/ob mice also showed that PPAR-gamma rather than PPAR-a binds to the -197/-184 region of GLUT2 promoter. Taken together, liver GLUT2 may be a direct target of PPAR-gamma ligand contributing to glucose transport into liver in a condition when PAPR-gamma expression is increased as in type 2 diabetes or in severe obesity. | - |
dc.language | English | - |
dc.publisher | KOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGY | - |
dc.subject | ACTIVATED RECEPTOR-GAMMA | - |
dc.subject | PPAR-GAMMA | - |
dc.subject | NF-Y | - |
dc.subject | DIABETES-MELLITUS | - |
dc.subject | GENE PROMOTER | - |
dc.subject | FUNCTIONAL-CHARACTERIZATION | - |
dc.subject | DIFFERENTIAL EXPRESSION | - |
dc.subject | TRANSCRIPTION FACTOR | - |
dc.subject | ANTIDIABETIC AGENT | - |
dc.subject | INSULIN-RESISTANCE | - |
dc.title | Identification and characterization of peroxisome proliferator response element in the mouse GLUT2 promoter | - |
dc.type | Article | - |
dc.identifier.wosid | 000229192700005 | - |
dc.identifier.scopusid | 2-s2.0-18744385555 | - |
dc.type.rims | ART | - |
dc.citation.volume | 37 | - |
dc.citation.beginningpage | 101 | - |
dc.citation.endingpage | 110 | - |
dc.citation.publicationname | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.contributor.localauthor | Kim, Il-Doo | - |
dc.contributor.nonIdAuthor | Im, SS | - |
dc.contributor.nonIdAuthor | Kim, JW | - |
dc.contributor.nonIdAuthor | Kim, TH | - |
dc.contributor.nonIdAuthor | Song, XL | - |
dc.contributor.nonIdAuthor | Kim, SY | - |
dc.contributor.nonIdAuthor | Ahn, YH | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | GLUT2 | - |
dc.subject.keywordAuthor | liver | - |
dc.subject.keywordAuthor | promoter | - |
dc.subject.keywordAuthor | PPAR-gamma | - |
dc.subject.keywordAuthor | rosiglitazone | - |
dc.subject.keywordAuthor | type 2 diabetes | - |
dc.subject.keywordPlus | ACTIVATED RECEPTOR-GAMMA | - |
dc.subject.keywordPlus | PPAR-GAMMA | - |
dc.subject.keywordPlus | NF-Y | - |
dc.subject.keywordPlus | DIABETES-MELLITUS | - |
dc.subject.keywordPlus | GENE PROMOTER | - |
dc.subject.keywordPlus | FUNCTIONAL-CHARACTERIZATION | - |
dc.subject.keywordPlus | DIFFERENTIAL EXPRESSION | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | ANTIDIABETIC AGENT | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
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