Identification and characterization of peroxisome proliferator response element in the mouse GLUT2 promoter

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In the present study, we show that the expression of type 2 glucose transporter isoform (GLUT2) could be regulated by PPAR-gamma in the liver. Rosiglitazone, PPAR-gamma agonist, activated the GLUT2 mRNA level in the primary cultured hepatocytes and Alexander cells, when these cells were transfected with PPAR-gamma/RXR-alpha. We have localized the peroxisome proliferator response element in the mouse GLUT2 promoter by serial deletion studies and site-directed mutagenesis. Chromatin immunoprecipitation assay using ob/ob mice also showed that PPAR-gamma rather than PPAR-a binds to the -197/-184 region of GLUT2 promoter. Taken together, liver GLUT2 may be a direct target of PPAR-gamma ligand contributing to glucose transport into liver in a condition when PAPR-gamma expression is increased as in type 2 diabetes or in severe obesity.
Publisher
KOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGY
Issue Date
2005-04
Language
English
Article Type
Article
Keywords

ACTIVATED RECEPTOR-GAMMA; PPAR-GAMMA; NF-Y; DIABETES-MELLITUS; GENE PROMOTER; FUNCTIONAL-CHARACTERIZATION; DIFFERENTIAL EXPRESSION; TRANSCRIPTION FACTOR; ANTIDIABETIC AGENT; INSULIN-RESISTANCE

Citation

EXPERIMENTAL AND MOLECULAR MEDICINE, v.37, pp.101 - 110

ISSN
1226-3613
URI
http://hdl.handle.net/10203/92499
Appears in Collection
MS-Journal Papers(저널논문)
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