DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Youngseok | ko |
dc.contributor.author | Lee, Yong | ko |
dc.contributor.author | Lee, Jaejung | ko |
dc.contributor.author | Bang, Sunhoe | ko |
dc.contributor.author | Hyun, Seogang | ko |
dc.contributor.author | Kang, Jongkyun | ko |
dc.contributor.author | Hong, Sung-Tae | ko |
dc.contributor.author | Bae, Eenkyung | ko |
dc.contributor.author | Kaang, Bong-Kiun | ko |
dc.contributor.author | Kim, Jaeseob | ko |
dc.date.accessioned | 2013-03-07T11:59:02Z | - |
dc.date.available | 2013-03-07T11:59:02Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2005-03 | - |
dc.identifier.citation | NATURE GENETICS, v.37, no.3, pp.305 - 310 | - |
dc.identifier.issn | 1061-4036 | - |
dc.identifier.uri | http://hdl.handle.net/10203/90120 | - |
dc.description.abstract | Several transient receptor potential channels were recently found to be activated by temperature stimuli in vitro(1-1)4. Their physiological and behavioral roles are largely unknown. From a temperature-preference behavior screen of 27, 000 Drosophila melanogaster P-insertion mutants, we isolated a gene, named pyrexia (pyx), encoding a new transient receptor potential channel. Pyx was opened by temperatures above 40 degreesC in Xenopus laevis oocytes and HEK293T cells. It was ubiquitously expressed along the dendrites of a subset of peripheral nervous system neurons and was more permeable to K(+) than to Na(+). Although some pyx alleles resulted in abnormal temperature preferences, pyx null flies did not have significantly different temperature preferences than wild-type flies. But 60% of pyx null flies were paralyzed within 3 min of exposure to 40 degreesC, whereas only 9% of wild-type flies were paralyzed by the same stimulus. From these findings, we propose that the primary in vivo role of Pyx is to protect flies from high-temperature stress. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | HEAT-EVOKED ACTIVATION | - |
dc.subject | CAPSAICIN-RECEPTOR | - |
dc.subject | EXPRESSION SYSTEM | - |
dc.subject | TRP CHANNEL | - |
dc.subject | ION-CHANNEL | - |
dc.subject | THERMOSENSATION | - |
dc.subject | IDENTIFICATION | - |
dc.subject | NOCICEPTION | - |
dc.subject | PROTEIN | - |
dc.subject | NEURONS | - |
dc.title | Pyrexia is a new thermal transient receptor potential channel endowing tolerance to high temperatures in Drosophila melanogaster | - |
dc.type | Article | - |
dc.identifier.wosid | 000227297800023 | - |
dc.identifier.scopusid | 2-s2.0-20144376841 | - |
dc.type.rims | ART | - |
dc.citation.volume | 37 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 305 | - |
dc.citation.endingpage | 310 | - |
dc.citation.publicationname | NATURE GENETICS | - |
dc.identifier.doi | 10.1038/ng1513 | - |
dc.contributor.localauthor | Kim, Jaeseob | - |
dc.contributor.nonIdAuthor | Lee, Yong | - |
dc.contributor.nonIdAuthor | Lee, Jaejung | - |
dc.contributor.nonIdAuthor | Hong, Sung-Tae | - |
dc.contributor.nonIdAuthor | Bae, Eenkyung | - |
dc.contributor.nonIdAuthor | Kaang, Bong-Kiun | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | HEAT-EVOKED ACTIVATION | - |
dc.subject.keywordPlus | CAPSAICIN-RECEPTOR | - |
dc.subject.keywordPlus | EXPRESSION SYSTEM | - |
dc.subject.keywordPlus | TRP CHANNEL | - |
dc.subject.keywordPlus | ION-CHANNEL | - |
dc.subject.keywordPlus | THERMOSENSATION | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | NOCICEPTION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | NEURONS | - |
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