Macrophages, myofibroblasts and mast cells in a rat liver infected with Capillaria hepatica

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We trapped a rat (Rattus norvegicus) infected with Capillaria hepatica. At necropsy, grossly yellowish-white nodules (2-3 mm in diameter) were noted to be scattered on the liver's surface. Microscopically, granulomatous and fibrotic nodules that contained the eggs and/or adult worms of Capillaria hepatica were detected in the liver. Septal fibrosis was diffusely formed throughout the liver. There were a number of ED1-positive macrophages located in the sinusoids of the pseudolobules. On the double staining, myofibroblasts and mast cells were generally observed within the fibrous septa with the mast cells in close proximity to the myofibroblasts. We suggest that the interactions between macrophages, myofibroblasts and mast cells play a role in the septal fibrosis observed in rats infected by Capillaria hepatica.
Publisher
KOREAN SOC VETERINARY SCIENCE
Issue Date
2008-06
Language
English
Article Type
Article
Keywords

SEPTAL FIBROSIS; PORCINE SERUM

Citation

JOURNAL OF VETERINARY SCIENCE, v.9, no.2, pp.211 - 213

ISSN
1229-845X
URI
http://hdl.handle.net/10203/89922
Appears in Collection
MSE-Journal Papers(저널논문)
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