The multi-step phosphorelay mechanism of unorthodox two-component systems in E. coli realizes ultrasensitivity to stimuli while maintaining robustness to noises

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E. coli has two-component systems composed of histidine kinase proteins and response regulator proteins. For a given extracellular stimulus, a histidine kinase senses the stimulus, autophosphorylates and then passes the phosphates to the cognate response regulators. The histidine kinase in an orthodox two-component system has only one histidine domain where the autophosphorylation occurs, but a histidine kinase in some unusual two-component systems (unorthodox two-component systems) has two histidine domains and one aspartate domain. So, the unorthodox two-component systems have more complex phosphorelay mechanisms than orthodox two-component systems. In general, the two-component systems are required to promptly respond to external stimuli for survival of E. coli. In this respect, the complex multi-step phosphorelay mechanism seems to be disadvantageous, but there are several unorthodox two-component systems in E. coli. In this paper, we investigate the reason why such unorthodox two-component systems are present in E. coli. For this purpose, we have developed simplified mathematical models of both orthodox and unorthodox two-component systems and analyzed their dynamical characteristics through extensive computer simulations. We have finally revealed that the unorthodox two-component systems realize ultrasensitive responses to external stimuli and also more robust responses to noises than the orthodox two-component systems. (c) 2006 Elsevier Ltd. All rights reserved.
Publisher
ELSEVIER SCI LTD
Issue Date
2006-12
Language
English
Article Type
Article
Keywords

SIGNAL-TRANSDUCTION SYSTEM; TORR RESPONSE REGULATOR; ESCHERICHIA-COLI; SENSOR; PHOSPHORYLATION; SENSITIVITY; BVGAS; EVGAS; BARA

Citation

COMPUTATIONAL BIOLOGY AND CHEMISTRY, v.30, pp.438 - 444

ISSN
1476-9271
DOI
10.1016/j.compbiolchem.2006.09.004
URI
http://hdl.handle.net/10203/89694
Appears in Collection
BiS-Journal Papers(저널논문)
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