DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, IH | ko |
dc.contributor.author | Jung, MW | ko |
dc.contributor.author | Mori, H | ko |
dc.contributor.author | Mook-Jung, I | ko |
dc.date.accessioned | 2013-03-06T05:46:43Z | - |
dc.date.available | 2013-03-06T05:46:43Z | - |
dc.date.created | 2013-02-20 | - |
dc.date.created | 2013-02-20 | - |
dc.date.issued | 2001-07 | - |
dc.identifier.citation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.285, no.3, pp.680 - 688 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | http://hdl.handle.net/10203/86004 | - |
dc.description.abstract | Whether zinc interacts with presenilin 1 (PS1), one of the causative genes of familial Alzheimer's disease (AD), is not known. Here we report that zinc modulates the synthesis of PSI. Exogenous zinc enhanced the amount of C-terminal fragments of PS1 (PS1-CTF) in neonatal mouse cortical cultures in a dose-dependent manner. Zinc also induced cell death in a dose-dependent manner. These effects of zinc were not mimicked by calcium, copper, or iron, and were blocked by a zinc-specific chelator, TPEN. Experiments using metabolic labeling and cycloheximide treatment revealed that zinc increased PS1-CTF by elevating the de novo synthesis of PS1. Time course experiments revealed that cell death commenced sooner (0.5-1 h) than enhancement of PS1-CTF (1-2 h) following zinc treatment. However, the amount of PS1-CTF remained unchanged during etoposide- or H2O2-induced cell death, suggesting that enhancement of PSI synthesis is specifically correlated with zinc-induced cell death. (C) 2001 Academic Press. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC | - |
dc.subject | AMYLOID PRECURSOR PROTEIN | - |
dc.subject | GAMMA-SECRETASE ACTIVITY | - |
dc.subject | HISTOCHEMICALLY-REACTIVE ZINC | - |
dc.subject | ALZHEIMER A-BETA | - |
dc.subject | TRANSGENIC MICE | - |
dc.subject | DISEASE | - |
dc.subject | NEURONS | - |
dc.subject | BRAIN | - |
dc.subject | ENDOPROTEOLYSIS | - |
dc.subject | APOPTOSIS | - |
dc.title | Zinc enhances synthesis of presenilin 1 in mouse primary cortical culture | - |
dc.type | Article | - |
dc.identifier.wosid | 000170131400018 | - |
dc.identifier.scopusid | 2-s2.0-0034811346 | - |
dc.type.rims | ART | - |
dc.citation.volume | 285 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 680 | - |
dc.citation.endingpage | 688 | - |
dc.citation.publicationname | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.identifier.doi | 10.1006/bbrc.2001.5243 | - |
dc.contributor.localauthor | Jung, MW | - |
dc.contributor.nonIdAuthor | Park, IH | - |
dc.contributor.nonIdAuthor | Mori, H | - |
dc.contributor.nonIdAuthor | Mook-Jung, I | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | presenilin 1 | - |
dc.subject.keywordAuthor | zinc | - |
dc.subject.keywordAuthor | beta amyloid | - |
dc.subject.keywordAuthor | cell death | - |
dc.subject.keywordAuthor | TPEN | - |
dc.subject.keywordPlus | AMYLOID PRECURSOR PROTEIN | - |
dc.subject.keywordPlus | GAMMA-SECRETASE ACTIVITY | - |
dc.subject.keywordPlus | HISTOCHEMICALLY-REACTIVE ZINC | - |
dc.subject.keywordPlus | ALZHEIMER A-BETA | - |
dc.subject.keywordPlus | TRANSGENIC MICE | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | ENDOPROTEOLYSIS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
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