DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nascimbeni, M | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.contributor.author | Chiriboga, L | ko |
dc.contributor.author | Kleiner, DE | ko |
dc.contributor.author | Rehermann, B | ko |
dc.date.accessioned | 2013-03-06T03:47:02Z | - |
dc.date.available | 2013-03-06T03:47:02Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2004-07 | - |
dc.identifier.citation | BLOOD, v.104, no.2, pp.478 - 486 | - |
dc.identifier.issn | 0006-4971 | - |
dc.identifier.uri | http://hdl.handle.net/10203/85719 | - |
dc.description.abstract | Although an increased frequency of CD4(+)CD8(+) T cells has been observed in the peripheral blood during viral infections, their role, function, and biologic significance are still poorly understood. Here we demonstrate that the circulating CD4+CD8+ T-cell population contains mature effector memory lymphocytes specific for antigens of multiple past, latent, and high-level persistent viral infections. Upon in vitro antigenic challenge, a higher frequency of CD4+CD8+ than single-positive cells displayed a T helper 1/T cytotoxic 1 (Th1/Tc1) cytokine profile and proliferated. Ex vivo, more double-positive than single-positive cells exhibited a differentiated phenotype. Accordingly, their lower T-cell receptor excision circles (TREC) content and shorter telomeres proved they had divided more frequently than single-positive cells. Consistent with expression of the tissue-homing marker CXCR3, CD4(+)CD8(+) T cells were demonstrated in situ at the site of persistent viral infection (le, in the liver during chronic hepatitis C). Finally, a prospective analysis of hepatitis C virus (HCV) infection in a chimpanzee, the only animal model for HCV infection, showed a close correlation between the frequency of activated CD4(+)CD8(+) T cells and viral kinetics. Collectively, these findings demonstrate that peripheral CD4(+)CD8(+) T cells take part in the adaptive immune response against infectious pathogens and broaden the perception of the T-cell populations involved in antiviral immune responses. (C) 2004 by The American Society of Hematology. | - |
dc.language | English | - |
dc.publisher | AMER SOC HEMATOLOGY | - |
dc.subject | HEPATITIS-C VIRUS | - |
dc.subject | CELLULAR IMMUNE-RESPONSES | - |
dc.subject | PERSISTENT EXPANSIONS | - |
dc.subject | CYTOTOXIC ACTIVITY | - |
dc.subject | EXPRESS CD4 | - |
dc.subject | HUMAN LIVER | - |
dc.subject | IN-VIVO | - |
dc.subject | LYMPHOCYTES | - |
dc.subject | BLOOD | - |
dc.subject | INFECTION | - |
dc.title | Peripheral CD4(+)CD8(+) T cells are differentiated effector memory cells with antiviral functions | - |
dc.type | Article | - |
dc.identifier.wosid | 000222571400033 | - |
dc.identifier.scopusid | 2-s2.0-3142590367 | - |
dc.type.rims | ART | - |
dc.citation.volume | 104 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 478 | - |
dc.citation.endingpage | 486 | - |
dc.citation.publicationname | BLOOD | - |
dc.identifier.doi | 10.1182/blood-2003-12-4395 | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.nonIdAuthor | Nascimbeni, M | - |
dc.contributor.nonIdAuthor | Chiriboga, L | - |
dc.contributor.nonIdAuthor | Kleiner, DE | - |
dc.contributor.nonIdAuthor | Rehermann, B | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | HEPATITIS-C VIRUS | - |
dc.subject.keywordPlus | CELLULAR IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | PERSISTENT EXPANSIONS | - |
dc.subject.keywordPlus | CYTOTOXIC ACTIVITY | - |
dc.subject.keywordPlus | EXPRESS CD4 | - |
dc.subject.keywordPlus | HUMAN LIVER | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
dc.subject.keywordPlus | BLOOD | - |
dc.subject.keywordPlus | INFECTION | - |
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