Peripheral CD4(+)CD8(+) T cells are differentiated effector memory cells with antiviral functions

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dc.contributor.authorNascimbeni, Mko
dc.contributor.authorShin, Eui-Cheolko
dc.contributor.authorChiriboga, Lko
dc.contributor.authorKleiner, DEko
dc.contributor.authorRehermann, Bko
dc.date.accessioned2013-03-06T03:47:02Z-
dc.date.available2013-03-06T03:47:02Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2004-07-
dc.identifier.citationBLOOD, v.104, no.2, pp.478 - 486-
dc.identifier.issn0006-4971-
dc.identifier.urihttp://hdl.handle.net/10203/85719-
dc.description.abstractAlthough an increased frequency of CD4(+)CD8(+) T cells has been observed in the peripheral blood during viral infections, their role, function, and biologic significance are still poorly understood. Here we demonstrate that the circulating CD4+CD8+ T-cell population contains mature effector memory lymphocytes specific for antigens of multiple past, latent, and high-level persistent viral infections. Upon in vitro antigenic challenge, a higher frequency of CD4+CD8+ than single-positive cells displayed a T helper 1/T cytotoxic 1 (Th1/Tc1) cytokine profile and proliferated. Ex vivo, more double-positive than single-positive cells exhibited a differentiated phenotype. Accordingly, their lower T-cell receptor excision circles (TREC) content and shorter telomeres proved they had divided more frequently than single-positive cells. Consistent with expression of the tissue-homing marker CXCR3, CD4(+)CD8(+) T cells were demonstrated in situ at the site of persistent viral infection (le, in the liver during chronic hepatitis C). Finally, a prospective analysis of hepatitis C virus (HCV) infection in a chimpanzee, the only animal model for HCV infection, showed a close correlation between the frequency of activated CD4(+)CD8(+) T cells and viral kinetics. Collectively, these findings demonstrate that peripheral CD4(+)CD8(+) T cells take part in the adaptive immune response against infectious pathogens and broaden the perception of the T-cell populations involved in antiviral immune responses. (C) 2004 by The American Society of Hematology.-
dc.languageEnglish-
dc.publisherAMER SOC HEMATOLOGY-
dc.subjectHEPATITIS-C VIRUS-
dc.subjectCELLULAR IMMUNE-RESPONSES-
dc.subjectPERSISTENT EXPANSIONS-
dc.subjectCYTOTOXIC ACTIVITY-
dc.subjectEXPRESS CD4-
dc.subjectHUMAN LIVER-
dc.subjectIN-VIVO-
dc.subjectLYMPHOCYTES-
dc.subjectBLOOD-
dc.subjectINFECTION-
dc.titlePeripheral CD4(+)CD8(+) T cells are differentiated effector memory cells with antiviral functions-
dc.typeArticle-
dc.identifier.wosid000222571400033-
dc.identifier.scopusid2-s2.0-3142590367-
dc.type.rimsART-
dc.citation.volume104-
dc.citation.issue2-
dc.citation.beginningpage478-
dc.citation.endingpage486-
dc.citation.publicationnameBLOOD-
dc.identifier.doi10.1182/blood-2003-12-4395-
dc.contributor.localauthorShin, Eui-Cheol-
dc.contributor.nonIdAuthorNascimbeni, M-
dc.contributor.nonIdAuthorChiriboga, L-
dc.contributor.nonIdAuthorKleiner, DE-
dc.contributor.nonIdAuthorRehermann, B-
dc.type.journalArticleArticle-
dc.subject.keywordPlusHEPATITIS-C VIRUS-
dc.subject.keywordPlusCELLULAR IMMUNE-RESPONSES-
dc.subject.keywordPlusPERSISTENT EXPANSIONS-
dc.subject.keywordPlusCYTOTOXIC ACTIVITY-
dc.subject.keywordPlusEXPRESS CD4-
dc.subject.keywordPlusHUMAN LIVER-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlusLYMPHOCYTES-
dc.subject.keywordPlusBLOOD-
dc.subject.keywordPlusINFECTION-
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