Radical-mediated synthesis of trifluoroethyl amines and trifluoromethyl ketones from alkyl iodides

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Radical reaction of alkyl iodides with trifluoromethyl phenylsulfonyl oxime ether 10 and hexamethylditin at 300 nm in benzene afforded the corresponding trifluoromethyl oxime ethers 11 in high yields, which were reduced into the 2,2,2-trifluoroethyl amines with lithium aluminium hydride. The trifluoroethyl amines could be converted into the corresponding trifluoromethyl ketones by treatment with NBS and DBU. (C) 2002 Elsevier Science Ltd. All rights reserved.
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Issue Date
2002-09
Language
English
Article Type
Article
Keywords

OXIME ETHERS; ACYLATION APPROACH; CARBOXYLIC-ACIDS; ESTERS; (TRIFLUOROMETHYL)TRIMETHYLSILANE; REAGENTS; INHIBITORS; REDUCTION

Citation

TETRAHEDRON LETTERS, v.43, no.40, pp.7189 - 7191

ISSN
0040-4039
URI
http://hdl.handle.net/10203/83790
Appears in Collection
CH-Journal Papers(저널논문)
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