DC Field | Value | Language |
---|---|---|
dc.contributor.author | Paladini, CA | ko |
dc.contributor.author | Fiorillo, Christopher D. | ko |
dc.contributor.author | Morikawa, H | ko |
dc.contributor.author | Williams, JT | ko |
dc.date.accessioned | 2013-03-04T13:49:47Z | - |
dc.date.available | 2013-03-04T13:49:47Z | - |
dc.date.created | 2012-03-19 | - |
dc.date.created | 2012-03-19 | - |
dc.date.issued | 2001-03 | - |
dc.identifier.citation | NATURE NEUROSCIENCE, v.4, no.3, pp.275 - 281 | - |
dc.identifier.issn | 1097-6256 | - |
dc.identifier.uri | http://hdl.handle.net/10203/82839 | - |
dc.description.abstract | Amphetamine is a highly addictive psychostimulant that promotes the release of the catecholamines dopamine and norepinephrine. Amphetamine-induced release of dopamine in the midbrain inhibits the activity of dopamine neurons through activation of D-2 dopamine autoreceptors. Here we show that amphetamine may also excite dopamine neurons through modulation of glutamate neurotransmission. Amphetamine potently inhibits metabotropic glutamate receptor (mGluR)-mediated IPSPs in dopamine neurons, but has no effect on ionotropic glutamate receptor-mediated EPSCs. Amphetamine desensitizes the mGluR-mediated hyperpolarization through release of dopamine, activation of postsynaptic alpha (1) adrenergic receptors, and suppression of InsP(3)-induced calcium release from internal stores. By selectively suppressing the inhibitory component of glutamate-mediated transmission, amphetamine may promote burst firing of dopamine neurons. Through this mechanism, amphetamine may enhance phasic release of dopamine, which is important in the neural processing of reward. | - |
dc.language | English | - |
dc.publisher | NATURE AMERICA INC | - |
dc.subject | VENTRAL TEGMENTAL AREA | - |
dc.subject | EXCITATORY SYNAPTIC TRANSMISSION | - |
dc.subject | RAT NUCLEUS-ACCUMBENS | - |
dc.subject | SUBSTANTIA-NIGRA | - |
dc.subject | RECEPTORS | - |
dc.subject | COCAINE | - |
dc.subject | LOCOMOTOR | - |
dc.subject | MODULATION | - |
dc.subject | PRAZOSIN | - |
dc.subject | RELEASE | - |
dc.title | Amphetamine selectively blocks inhibitory glutamate transmission in dopamine neurons | - |
dc.type | Article | - |
dc.identifier.wosid | 000167178300015 | - |
dc.identifier.scopusid | 2-s2.0-0035119780 | - |
dc.type.rims | ART | - |
dc.citation.volume | 4 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 275 | - |
dc.citation.endingpage | 281 | - |
dc.citation.publicationname | NATURE NEUROSCIENCE | - |
dc.identifier.doi | 10.1038/85124 | - |
dc.contributor.localauthor | Fiorillo, Christopher D. | - |
dc.contributor.nonIdAuthor | Paladini, CA | - |
dc.contributor.nonIdAuthor | Morikawa, H | - |
dc.contributor.nonIdAuthor | Williams, JT | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | VENTRAL TEGMENTAL AREA | - |
dc.subject.keywordPlus | EXCITATORY SYNAPTIC TRANSMISSION | - |
dc.subject.keywordPlus | RAT NUCLEUS-ACCUMBENS | - |
dc.subject.keywordPlus | SUBSTANTIA-NIGRA | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | COCAINE | - |
dc.subject.keywordPlus | LOCOMOTOR | - |
dc.subject.keywordPlus | MODULATION | - |
dc.subject.keywordPlus | PRAZOSIN | - |
dc.subject.keywordPlus | RELEASE | - |
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