DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, YC | ko |
dc.contributor.author | Song, CH | ko |
dc.contributor.author | Lee, HB | ko |
dc.contributor.author | Oh, JL | ko |
dc.contributor.author | Rhee, YK | ko |
dc.contributor.author | Park, HS | ko |
dc.contributor.author | Koh, Gou Young | ko |
dc.date.accessioned | 2013-03-03T10:15:36Z | - |
dc.date.available | 2013-03-03T10:15:36Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2001-12 | - |
dc.identifier.citation | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY , v.108, pp.1021 - 1026 | - |
dc.identifier.issn | 0091-6749 | - |
dc.identifier.uri | http://hdl.handle.net/10203/78337 | - |
dc.description.abstract | Background: Toluene diisocyanate (TDI) is a leading cause of occupational asthma. TDI-induced asthma is an inflammatory disease of the airways that is associated with airway remodeling. However, there are little data available on the role of matrix metalloproteinases (MMPs) in TDI-induced asthma. Objective: We. evaluated whether MMP-9 participates in the airway inflammation in TDI-induced asthma. An additional aim of the present study was to determine whether MMP inhibitors could be effective therapeutic agents for TDI-induced asthma. Methods: We developed a murine model of TDI-induced asthma to examine the involvement of MMPs by performing 2 sensitizations with 3% TDI and 1 challenge with 1% TDI using ultrasonic nebulization. Results: Marine TDI-induced asthma includes findings of (1) increased inflammatory cells, including neutrophils, lymphocytes, and eosinophils; (2) histologic changes, including infiltration of inflammatory cells around bronchioles, thickened airway epithelium, and accumulation of mucus and debris in the bronchioles; (3) increased MMP-9 activity in inflammatory cells in the airway lumen; and (4) airway hyperresponsiveness. Administration of an MMP inhibitor remarkably reduced all these pathophysiologic findings. Conclusion: We conclude that TDI-induced occupational asthma is associated with the induction of MMP-9 in inflammatory cells, and the inhibition of MMP-9 may be a good therapeutic strategy. | - |
dc.language | English | - |
dc.publisher | Mosby-Elsevier | - |
dc.title | A murine model of toluene diisocyanate-induced asthma can be treated with matrix metalloproteinase inhibitor | - |
dc.type | Article | - |
dc.identifier.wosid | 000172938400020 | - |
dc.identifier.scopusid | 2-s2.0-0035217088 | - |
dc.type.rims | ART | - |
dc.citation.volume | 108 | - |
dc.citation.beginningpage | 1021 | - |
dc.citation.endingpage | 1026 | - |
dc.citation.publicationname | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | - |
dc.identifier.doi | 10.1067/mai.2001.120132 | - |
dc.contributor.localauthor | Koh, Gou Young | - |
dc.contributor.nonIdAuthor | Lee, YC | - |
dc.contributor.nonIdAuthor | Song, CH | - |
dc.contributor.nonIdAuthor | Lee, HB | - |
dc.contributor.nonIdAuthor | Oh, JL | - |
dc.contributor.nonIdAuthor | Rhee, YK | - |
dc.contributor.nonIdAuthor | Park, HS | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | toluene diisocyanate | - |
dc.subject.keywordAuthor | matrix metalloproteinase | - |
dc.subject.keywordAuthor | asthma | - |
dc.subject.keywordAuthor | airway hyperresponsiveness | - |
dc.subject.keywordPlus | TISSUE INHIBITOR | - |
dc.subject.keywordPlus | POLYMORPHONUCLEAR NEUTROPHILS | - |
dc.subject.keywordPlus | BASEMENT-MEMBRANE | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | COLLAGENASE | - |
dc.subject.keywordPlus | MODULATION | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordPlus | FIBROSIS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | SPUTUM | - |
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