DC Field | Value | Language |
---|---|---|
dc.contributor.author | KIM, JK | ko |
dc.contributor.author | Choi, Byong-Seok | ko |
dc.date.accessioned | 2013-03-02T20:41:33Z | - |
dc.date.available | 2013-03-02T20:41:33Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 1995-03 | - |
dc.identifier.citation | EUROPEAN JOURNAL OF BIOCHEMISTRY, v.228, no.3, pp.849 - 854 | - |
dc.identifier.issn | 0014-2956 | - |
dc.identifier.uri | http://hdl.handle.net/10203/75430 | - |
dc.description.abstract | The DNA duplex-decamer containing a site-specific (6-4) photoadduct of thymidylyl(3'-->5')thymidine was generated by direct photolytic ultraviolet C irradiation of d(CGCATTACGC). The three-dimensional structure of the duplex (6-4) decamer, d(CGCAT[6-4]TACGC) . d(GCGTAATGCG), has been determined by two-dimensional NMR spectroscopy and a relaxation matrix refinement method. NMR data and structural calculations established that the formation of the (6-4) adduct in the B-DNA duplex retains Watson-Crick-type hydrogen bonding throughout the duplex except at the 3'-side of the (6-4) lesion where the T-->C transition mutation is predominantly targeted [LeClerc, J. E., Borden, A. and Lawrence, C. W. (1991) Proc. Natl Acad. Sci. USA 88, 9685-9689], but leads to a 44 degrees bending in the overall DNA helix. Perpendicular base orientation of the (6-4) lesion provides a structural basis where potential hydrogen bonding at the 3' sides of the (6-4) adduct with substituted nucleotide is improbable during replication under stringent conditions. | - |
dc.language | English | - |
dc.publisher | SPRINGER VERLAG | - |
dc.subject | CIS-SYN | - |
dc.subject | ESCHERICHIA-COLI | - |
dc.subject | THYMINE DIMERS | - |
dc.subject | CYCLOBUTANE | - |
dc.subject | H-1-NMR | - |
dc.subject | REPAIR | - |
dc.subject | CELLS | - |
dc.subject | GENE | - |
dc.title | THE SOLUTION STRUCTURE OF DNA DUPLEX-DECAMER CONTAINING THE (6-4) PHOTOPRODUCT OF THYMIDYLYL(3-]5)THYMIDINE BY NMR AND RELAXATION MATRIX REFINEMENT | - |
dc.type | Article | - |
dc.identifier.wosid | A1995QN89900039 | - |
dc.identifier.scopusid | 2-s2.0-0028927254 | - |
dc.type.rims | ART | - |
dc.citation.volume | 228 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 849 | - |
dc.citation.endingpage | 854 | - |
dc.citation.publicationname | EUROPEAN JOURNAL OF BIOCHEMISTRY | - |
dc.contributor.localauthor | Choi, Byong-Seok | - |
dc.contributor.nonIdAuthor | KIM, JK | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | (6-4) PHOTOPRODUCT | - |
dc.subject.keywordAuthor | PHOTOCHEMICALLY MODIFIED DNA | - |
dc.subject.keywordAuthor | NMR | - |
dc.subject.keywordAuthor | STRUCTURE | - |
dc.subject.keywordPlus | CIS-SYN | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI | - |
dc.subject.keywordPlus | THYMINE DIMERS | - |
dc.subject.keywordPlus | CYCLOBUTANE | - |
dc.subject.keywordPlus | H-1-NMR | - |
dc.subject.keywordPlus | REPAIR | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | GENE | - |
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