DC Field | Value | Language |
---|---|---|
dc.contributor.author | Duong, TQ | ko |
dc.contributor.author | Kim, Dae-Shik | ko |
dc.contributor.author | Ugurbil, K | ko |
dc.contributor.author | Kim, SG | ko |
dc.date.accessioned | 2013-03-02T13:02:00Z | - |
dc.date.available | 2013-03-02T13:02:00Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2000-08 | - |
dc.identifier.citation | MAGNETIC RESONANCE IN MEDICINE, v.44, no.2, pp.231 - 242 | - |
dc.identifier.issn | 0740-3194 | - |
dc.identifier.uri | http://hdl.handle.net/10203/73639 | - |
dc.description.abstract | The existence of the early-negative blood-oxygenation-level-dependent (BOLD) response is controversial and its practical utility for mapping brain functions with columnar spatial specificity remains questionable. To address these issues, gradient-echo BOLD fMRI studies were performed at 4.7 T and 9.4 T using the well-established orientation column model in the cat visual cortex. A robust transient early-negative BOLD response was consistently observed in anesthetized cat (-0.35 +/- 0.09%, mean +/- SD, n = 8 at 2.9 +/- 0.5 sec poststimulus onset for 4.7 T, TE = 31 ms; -0.29 +/- 0.10%, n = 4 at 3.0 +/- 0.8 sec poststimulus onset for 9.4 T, TE = 12 ms). In addition to its temporal evolution, the BOLD response also evolved dynamically in the spatial domain. The initially spatially localized early-negative signal appeared to dynamically drain from the active sites toward large vessels, followed by a wave of the delayed positive signal, which exhibited similar spatiotemporal dynamics. Only the early-negative BOLD response within 2 sec of the stimulus onset (not the entire dip) yielded columnar layouts without differential subtraction. The functional maps of two orthogonal orientations using the first 2-sec dip were indeed complementary. On the other hand, the delayed positive BOLD response appeared diffused and extended beyond the active sites. It was thus less suitable to resolve columnar layouts. These results have implications for the design and interpretation of the BOLD fMRI at columnar resolution. Magn Reson Med 44:231-242, 2000. (C) 2000 Wiley-Liss, Inc. | - |
dc.language | English | - |
dc.publisher | JOHN WILEY SONS INC | - |
dc.subject | HIGH MAGNETIC-FIELDS | - |
dc.subject | CAT VISUAL-CORTEX | - |
dc.subject | SENSORY STIMULATION | - |
dc.subject | FUNCTIONAL MRI | - |
dc.subject | HUMAN BRAIN | - |
dc.subject | OCULAR DOMINANCE | - |
dc.subject | STRIATE CORTEX | - |
dc.subject | BLOOD-FLOW | - |
dc.subject | IN-VIVO | - |
dc.subject | ACTIVATION | - |
dc.title | Spatiotemporal dynamics of the BOLD fMRI signals: Toward mapping submillimeter cortical columns using the early negative response | - |
dc.type | Article | - |
dc.identifier.wosid | 000088545600010 | - |
dc.identifier.scopusid | 2-s2.0-0033865462 | - |
dc.type.rims | ART | - |
dc.citation.volume | 44 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 231 | - |
dc.citation.endingpage | 242 | - |
dc.citation.publicationname | MAGNETIC RESONANCE IN MEDICINE | - |
dc.identifier.doi | 10.1002/1522-2594(200008)44:2<231::AID-MRM10>3.3.CO;2-K | - |
dc.contributor.localauthor | Kim, Dae-Shik | - |
dc.contributor.nonIdAuthor | Duong, TQ | - |
dc.contributor.nonIdAuthor | Ugurbil, K | - |
dc.contributor.nonIdAuthor | Kim, SG | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | early dip | - |
dc.subject.keywordAuthor | brain mapping | - |
dc.subject.keywordAuthor | deoxyhemoglobin | - |
dc.subject.keywordAuthor | oxygen consumption | - |
dc.subject.keywordAuthor | cerebral blood flow | - |
dc.subject.keywordAuthor | ocular dominance columns | - |
dc.subject.keywordAuthor | high magnetic field | - |
dc.subject.keywordAuthor | cat visual cortex | - |
dc.subject.keywordAuthor | optical imaging | - |
dc.subject.keywordAuthor | orientation columns | - |
dc.subject.keywordAuthor | hemodynamic response | - |
dc.subject.keywordPlus | HIGH MAGNETIC-FIELDS | - |
dc.subject.keywordPlus | CAT VISUAL-CORTEX | - |
dc.subject.keywordPlus | SENSORY STIMULATION | - |
dc.subject.keywordPlus | FUNCTIONAL MRI | - |
dc.subject.keywordPlus | HUMAN BRAIN | - |
dc.subject.keywordPlus | OCULAR DOMINANCE | - |
dc.subject.keywordPlus | STRIATE CORTEX | - |
dc.subject.keywordPlus | BLOOD-FLOW | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | ACTIVATION | - |
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