Asymmetric Synthesis of 1,2-Amino Alcohols Using (S)-Indoline Chiral Auxiliary," , , 2000, 12, 404-407

Abstract

Chiral hydrazones 1 reacted with aryl- or alkyl-lithiums at -78 degrees C in a short reaction time, within 10 min, to afford arylated or alkylated chiral hydrazines 3 with extremely high diastereoselectivity (up to >99% de) and high chemical yields. The hydrazines are readily converted to chiral amino alcohols 4. (C) 2000 Wiley-Liss,Inc.