NMR studies of the conformation and stability of the 4-aminomethyl-4,5,8-trimethylpsoralen (AMT) cross-linked DNA octamer duplex, d(GGGTACCC)(2)

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The 4'-aminomethyl-4,5',8-trimethylpsoralen (AMT) has been used as intercalating DNA binding drugs in the photo-chemotherapy of skin diseases. The conformation and stability of DNA octamer duplex, d (GGGTACCC)(2), cross-linked with AMT has been studied by NMR spectroscopy. All the proton resonances of the psoralen cross-linked octamer were assigned and meting temperature studies were carried out based on the assignment of the proton resonances. The aromatic proton chemical shift data suggest that the conformation of the helix cross-linked with psoralen is destabilized more to furanside of the psoralen, possibly due to the protrusion of the aminomethyl side chain of the psoralen.
Publisher
BIOCHEMICAL SOC REPUBLIC KOREA
Issue Date
1997-11
Language
English
Article Type
Article
Keywords

T7 RNA-POLYMERASE; ELONGATION COMPLEXES; PSORALEN; SITE; SPECIFICITY; MONOADDUCT; INCISION; TEMPLATE; REPAIR

Citation

JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, v.30, no.6, pp.421 - 425

ISSN
1225-8687
URI
http://hdl.handle.net/10203/67890
Appears in Collection
CH-Journal Papers(저널논문)
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