Taguchi's robust design method for optimization of lysophosphatidic acid production in an open reactor system

Cited 8 time in webofscience Cited 0 time in scopus
  • Hit : 184
  • Download : 0
The determination of appropriate parameters and parameter conditions is very important for the optimization of production of target materials. Taguchi's method has been used widely as the basis for development trials and optimization during industrial process design. Reaction variables which influence product yield are easily determined and their effects are revealed by just a few reactions, negating the need for extensive experimental investigation. There are usually some factors that are responsible for variations in process characteristics, so called noise factors. Controlling noise factors is very costly and difficult or impossible. Taguchi's experimental design method was examined to determine the control factors level that is less sensitive to the changes in environmental conditions and other noise factors without control of noise factors. In this study, optimization of lipase-catalyzed production of lysophosphatidic acid (LPA) which has various physiological functions was performed by Taguchi's method. We obtained LPA yields (66.5%) with low variance (5.32) at 400 RPM, molar ratio of 40:3 (mmol) (fatty acid:G-3-P), 48 h, and 50 degrees C. Thus, bioactive LPA with a desired fatty acid moiety could be produced with high yields and low variance despite various environmental noise factors.
Publisher
SPRINGER-VERLAG SINGAPORE PTE LTD
Issue Date
1998-02
Language
English
Article Type
Article
Keywords

LIPASE-CATALYZED SYNTHESIS; LINE QUALITY-CONTROL; LYSOPHOSPHOLIPIDS

Citation

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v.8, no.1, pp.81 - 88

ISSN
1017-7825
URI
http://hdl.handle.net/10203/67737
Appears in Collection
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 8 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0