DC Field | Value | Language |
---|---|---|
dc.contributor.author | CHOI, MJ | ko |
dc.contributor.author | HAN, HS | ko |
dc.contributor.author | Kim, Hyoung Man | ko |
dc.date.accessioned | 2013-02-24T09:37:12Z | - |
dc.date.available | 2013-02-24T09:37:12Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 1992-11 | - |
dc.identifier.citation | JOURNAL OF BIOCHEMISTRY, v.112, no.5, pp.694 - 699 | - |
dc.identifier.issn | 0021-924X | - |
dc.identifier.uri | http://hdl.handle.net/10203/56125 | - |
dc.description.abstract | With the ultimate aim of targeting cancer drugs to malignant tissues, liposomes containing polymeric phosphatidylethanolamine and a fatty acid were prepared. For this purpose diacetylenic phosphatidylethanolamine (DAPE), a phosphatidylethanolamine containing diacetylene, was synthesized. Liposomes containing DAPE, fatty acid, and either phosphatidylethanolamine (PE) or phosphatidylethanolamine-beta-oleoyl-gamma-palmitoyl (POPE) were then prepared. Polymerization of DAPE was effected by UV illumination. The polymeric liposomes so obtained were stable at physiological pH but became leaky below pH 6.5. Of various compositions studied, the greatest pH-sensitivity was found with liposomes composed of 35 mol% DAPE, 35 mol% POPE, and 30 mol% saturated fatty acid.The presence of blood plasma albumin decreased vesicle stability while apolipoprotein A-I (apo A-I) had the opposite effect and plasma as a whole had a slightly stabilizing effect. | - |
dc.language | English | - |
dc.publisher | JAPANESE BIOCHEMICAL SOC | - |
dc.subject | HIGH-DENSITY-LIPOPROTEIN | - |
dc.subject | OLEIC-ACID | - |
dc.subject | PHOSPHATIDYLCHOLINE VESICLES | - |
dc.subject | PHOSPHOLIPID POLYMERS | - |
dc.subject | UNILAMELLAR VESICLES | - |
dc.subject | IMMUNOLIPOSOMES | - |
dc.subject | DELIVERY | - |
dc.subject | DIOLEOYLPHOSPHATIDYLETHANOLAMINE | - |
dc.subject | HYPERTHERMIA | - |
dc.subject | PHASE | - |
dc.title | PH-SENSITIVE LIPOSOMES CONTAINING POLYMERIZED PHOSPHATIDYLETHANOLAMINE AND FATTY-ACID | - |
dc.type | Article | - |
dc.identifier.wosid | A1992JX77300020 | - |
dc.identifier.scopusid | 2-s2.0-0026440647 | - |
dc.type.rims | ART | - |
dc.citation.volume | 112 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 694 | - |
dc.citation.endingpage | 699 | - |
dc.citation.publicationname | JOURNAL OF BIOCHEMISTRY | - |
dc.contributor.nonIdAuthor | CHOI, MJ | - |
dc.contributor.nonIdAuthor | HAN, HS | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | HIGH-DENSITY-LIPOPROTEIN | - |
dc.subject.keywordPlus | OLEIC-ACID | - |
dc.subject.keywordPlus | PHOSPHATIDYLCHOLINE VESICLES | - |
dc.subject.keywordPlus | PHOSPHOLIPID POLYMERS | - |
dc.subject.keywordPlus | UNILAMELLAR VESICLES | - |
dc.subject.keywordPlus | IMMUNOLIPOSOMES | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | DIOLEOYLPHOSPHATIDYLETHANOLAMINE | - |
dc.subject.keywordPlus | HYPERTHERMIA | - |
dc.subject.keywordPlus | PHASE | - |
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