Synthesis of β-Lactams from β-Amino acids with organophosphorus compounds as condensing reagents = 축합제로 유기인 화합물을 사용하여 베타-아미노산으로부터 베타-락탐의 합성

Cited 0 time in webofscience Cited 0 time in scopus
  • Hit : 402
  • Download : 0
$\beta$-Lactam formation via the dehydration of $\beta$-amino acids has been developed using organophosphorus condensing reagents, which include Bis(5``-nitro-2``-pyridyl)-2,2,2-trichloroethyl phosphate and Bis(2,2,2-trichloroethyl)-5``-nitro-2``-pyridyl phosphate. The former reagent is much more effective than the latter. Using Bis(5``-nitro-2``-pyridyl)-2,2,2-trichloroethyl phosphate as a condensing reagent, N-substituted $\beta$-amino acids are cleanly cyclized into the corresponding $\beta$-lactams in high yields in acetonitrile or methylene chloride at room temperature, while the present method appeared to be less effective in the formation of $\beta$-lactams from N-unsubstituted $\beta$-amino acids.
Advisors
Kim, Sung-Gakresearcher김성각researcher
Description
한국과학기술원 : 화학과,
Publisher
한국과학기술원
Issue Date
1987
Identifier
65526/325007 / 000851353
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 화학과, 1987.2, [ iv, 49 p. ]

URI
http://hdl.handle.net/10203/32489
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=65526&flag=dissertation
Appears in Collection
CH-Theses_Master(석사논문)
Files in This Item
There are no files associated with this item.

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0