Noisy Delay Denoises Biochemical Oscillators

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Genetic oscillations are generated by delayed transcriptional negative feedback loops, wherein repressor proteins inhibit their own synthesis after a temporal production delay. This delay is distributed because it arises from a sequence of noisy processes, including transcription, translocation, translation, and folding. Because the delay determines repression timing and, therefore, oscillation period, it has been commonly believed that delay noise weakens oscillatory dynamics. Here, we demonstrate that noisy delay can surprisingly denoise genetic oscillators. Specifically, moderate delay noise improves the signal-to-noise ratio and sharpens oscillation peaks, all without impacting period and amplitude. We show that this denoising phenomenon occurs in a variety of well-studied genetic oscillators, and we use queueing theory to uncover the universal mechanisms that produce it.
Publisher
AMER PHYSICAL SOC
Issue Date
2024-02
Language
English
Article Type
Review
Citation

PHYSICAL REVIEW LETTERS, v.132, no.7

ISSN
0031-9007
DOI
10.1103/PhysRevLett.132.078402
URI
http://hdl.handle.net/10203/323115
Appears in Collection
MA-Journal Papers(저널논문)
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