(A) new, versatile protection of nucleic acids using arylsulfenyl chlorides = 아릴 설페닐 클로리드를 이용한 효과적인 핵산의 보호화

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Developments of efficient protecting groups are very important in the synthesis of oligonucleotides and sugar modifications. The arylsulfenates have been found to be versatile blocking groups for the hydroxyl functions such as sugar hydroxyls and for the amide moieties in nucleotides. 2``,3``,5``-Tri-O-acetyluridine or purine derivatives were treated with sodium hydride in acetonitrile or tetrahydrofuran at 20$^\circ$C and then followed by the addition of arylsulfenyl chlorides to result in the corresponding arylsulfenates at 4-position or at 6-position of purine selectively in excellent yields (90-95\%). Deblocking was easily performed at 20$^\circ$C by treating with thiophenol or with silica gel.
Advisors
Kim, Yong-Hae김용해
Description
한국과학기술원 : 화학과,
Publisher
한국과학기술원
Issue Date
1992
Identifier
59917/325007 / 000901446
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 화학과, 1992.2, [ viii, 56 p. ]

URI
http://hdl.handle.net/10203/32174
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=59917&flag=dissertation
Appears in Collection
CH-Theses_Master(석사논문)
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