DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Churchill, David-George | - |
dc.contributor.advisor | 쳐칠, 데이빗 | - |
dc.contributor.author | Park, Hyun-Young | - |
dc.contributor.author | 박현영 | - |
dc.date.accessioned | 2011-12-13T04:51:59Z | - |
dc.date.available | 2011-12-13T04:51:59Z | - |
dc.date.issued | 2011 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=468017&flag=dissertation | - |
dc.identifier.uri | http://hdl.handle.net/10203/32133 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 화학과, 2011.2, [ xxix, 167 p. ] | - |
dc.description.abstract | Schiff bases with the azomethine (-C=NR) group are a condensation product of a primary amine and a carbonyl group in which $H_2O$ is eliminated. These groups are easily able to chelate many types of metal ions. Hence, a range of metal complexations have been assessed and a great number of metal Schiff base complexes have been reported. Some of them have shown for stereo- / enantio-selective catalytic activity or antibacterial or anticancer effects. They also show a range of characteristics in terms of their geometry, magnetic and optical properties. Thus, research on metal-Schiff base complexes has wide-ranging implications in the fields of organic, inorganic, and biochemistry, and pharmacology fields. Here, based on an aqueous blue fluorescent dimeric $Zn^{2+}$-Schiff base complex characterized in previous work by us, we focused on in situ $Zn^{2+}$-Schiff base complexation using $Zn^{2+}$, aromatic aldehydes as a fluo-rophore, and amino acids in physiological aqueous media, with the solutions assayed through fluorescence measurements. These studies can provide useful and basic information on the design and synthesis of efficient $Zn^{2+}$ sensors with a good yield as well as allow for a better understanding of the formation of reversible Schiff base formation through self-assembly and their interactions with metal ions in biological systems. In Chapter 1, aqueous in situ $Zn^{2+}$-Schiff base formation was studied by fluorescence at the 50 μM level using salicylaldehyde and a homologous series of D/L-amino acids [$H_2NCH(COOH)(CH_2)_nNH_2 (n = 1 - 4)$]. MALDI-TOF MS spectrometry and UV-vis absorption, fluorescence and 1H NMR spectroscopy were used in characterization. The three components ($Zn^{2+}$, salicylaldehyde and $H_2NCH(COOH)(CH_2)_nNH_2$) were each titrated separately at different molar concentration ratios (0-10 equiv) and reaction times (> ~28 h) at a pH of 7.4 and RT (25~30℃). All trials generally showed fluorescence ($λ_{em}$ = 450-460 nm; $λ_{ex... | eng |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | in situ | - |
dc.subject | fluorescence | - |
dc.subject | Schiff base | - |
dc.subject | Zinc(II) | - |
dc.subject | lysine homologues | - |
dc.subject | 라이신 유사체 | - |
dc.subject | 자발적 형성 | - |
dc.subject | 형광 | - |
dc.subject | 쉬프 염기 | - |
dc.subject | 아연(II) | - |
dc.title | Studies of the aqueous formation of highly blue fluorescent $Zn^{2+}$-Schiff base complexes at physiological pH | - |
dc.title.alternative | 생리적인 수소 이온 농도에서 청색 형광을 내는 수용성 쉬프 염기-아연(II) 화합물의 형성에 관한 연구 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 468017/325007 | - |
dc.description.department | 한국과학기술원 : 화학과, | - |
dc.identifier.uid | 020093612 | - |
dc.contributor.localauthor | Churchill, David-George | - |
dc.contributor.localauthor | 쳐칠, 데이빗 | - |
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