The rapid growth of data-intensive applications has significantly heightened the concerns about power consumption in current computing systems. From this perspective, there have been substantial efforts to implement ultra-low power systems by integrating nanoelectromechanical non-volatile switches (NEM-NVS) with near-zero leakage current into standard complementary metal-oxide-semiconductor (CMOS) circuits. To practically harness the potential of the NEM-NVS, it is imperative to achieve high performance, such as low voltage, high on/off ratio, and high reliability, while simultaneously ensuring wafer-scale CMOS compatibility. However, achieving these requirements is still challenging, primarily due to their electrostatic operation, in-plane electrode configuration, and conventional fabrication methods. Here, an electro-thermally actuated nanomechanical non-volatile switch (ETAN-NVS) with an out-of-plane electrode configuration along with an 8-inch wafer-scale CMOS-compatible fabrication method is reported. By introducing the electrothermal mechanism into a vertically actuated buckling nanostructure, the fabricated ETAN-NVS attains CMOS-level voltage (<2.4 V), a high on/off ratio (>10(8)), and exceptional reliability (>1300 cycles). Moreover, a successful wafer-scale demonstration of the ETAN-NVS using only a CMOS-compatible process paves the way for 3D integration with CMOS logic.