Cholesterol-containing non-ionic amphiphilic polymers : the properties and suprastructures = 콜레스테롤을 포함하는 비이온 양친매성 고분자의 성질과 초구조the properties and suprastructures

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Cholesterol-containing amphiphilic monomers, 1-ethenyl-3-(8-(cholest-5-en-3$\beta$-yloxy)-3,6-dioxaoctyl)-2-pyrrolidone (ECDP) and 1-ethenyl-3-(6-(cholest-5-en-3$\beta$-yloxy)hexyl)-2-pyrrolidone (ECHP), and cholesterol-containing amphiphilic polymers, poly(ECDP-co-N-vinylpyrrolidone) and poly(ECHP-co-N-vinylpyrrolidone), were synthesised, and their properties and suprastructures were investigated. ECDP formed vesicles in water by sonication, whereas ECHP did not. The polymerization of preformed vesicles derived from ECDP in water by water-soluble initiator resulted in the formation of polymeric vesicles of ECDP which were more stable to the addition of ethanol and tannic acid than the monomeric vesicles exhibiting higher long-term stability. The solution behaviors and the suprastructures of the cholesterol-containing amphiphilic polymers were influenced by copolymer composition and molecular weight. The polymers with low N-vinylpyrrolidone (NVP) content, apparently insoluble in water, were dispersed by sonication or by injection of organic solution into water to form vesicles. The more water-soluble polymers with high NVP content formed hydrophobic microdomains in water into which cholesterol was efficiently incorporated. The polymers underwent morphological change as cholesterol was solubilized and discrete lamellar bilayers were observed by electron microscope. Thus formed bilayers were considered to be responsible for the efficient cholesterol solubilization of the amphiphilic polymers. Some resemblances to certain biological membrane systems were found in the present solubilization systems.
Advisors
Shim, Hong-KuresearcherCho, I-Whanresearcher심홍구researcher조의환researcher
Description
한국과학기술원 : 화학과,
Publisher
한국과학기술원
Issue Date
1994
Identifier
68929/325007 / 000885443
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 화학과, 1994.2, [ xi, 108 p. ]

URI
http://hdl.handle.net/10203/31387
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=68929&flag=dissertation
Appears in Collection
CH-Theses_Ph.D.(박사논문)
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