Studies on Tc-99m complexes with diastereomericdimercaptosuccinic acids = 부분입체이성질성 디메르캅토 숙신산들으 Tc-99m 착체들에 관한 연구

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The four stereoisomeric $^99mTc$-DMSA complexes, Complex A and B from meso ligand COmplex I and II from dl ligand, were prepared and examined their properties. The stereoisomeric complexes were proven to have the different biochemical and chemical properties such as thermal stability, UV absorption spectra, lipophilicity and protein bindability. The biodistribution of the four complexes in tumor bearing animals was studied. Both Complex A and I accumulated in kidneys with high affinity but Complex I had much higher uptake on kidneys than Complex A. Both Complex B and II were studied particularly focusing on the tumor affinity compared to the complexes known as tumor seeking agents. The results indicated that the two complexes were of importance for possible use in tumor detection.
Advisors
Kim, Jae-RokShim, Sang-Chul김재록심상철
Description
한국과학기술원 : 화학과,
Publisher
한국과학기술원
Issue Date
1989
Identifier
61255/325007 / 000835815
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 화학과, 1989.2, [ ix, 113 p. ]

URI
http://hdl.handle.net/10203/31312
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=61255&flag=dissertation
Appears in Collection
CH-Theses_Ph.D.(박사논문)
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