External globus pallidus input to the dorsal striatum regulates habitual seeking behavior in male mice

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The external globus pallidus (GPe) coordinates action-selection through GABAergic projections throughout the basal ganglia. GPe arkypallidal (arky) neurons project exclusively to the dorsal striatum, which regulates goal-directed and habitual seeking. However, the role of GPe arky neurons in reward-seeking remains unknown. Here, we identified that a majority of arky neurons target the dorsolateral striatum (DLS). Using fiber photometry, we found that arky activities were higher during random interval (RI; habit) compared to random ratio (RR; goal) operant conditioning. Support vector machine analysis demonstrated that arky neuron activities have sufficient information to distinguish between RR and RI behavior. Genetic ablation of this arky(GPe & RARR;DLS) circuit facilitated a shift from goal-directed to habitual behavior. Conversely, chemogenetic activation globally reduced seeking behaviors, which was blocked by systemic D1R agonism. Our findings reveal a role of this arky(GPe & RARR;DLS) circuit in constraining habitual seeking in male mice, which is relevant to addictive behaviors and other compulsive disorders. The external part of the globus pallidus is involved in action-selection. Here, the authors investigate the function of an arkypallidal neuronal circuit to the dorsolateral striatum in goal-directed and habitual-seeking behaviors in male mice.
Publisher
NATURE PORTFOLIO
Issue Date
2023-07
Language
English
Article Type
Article
Citation

NATURE COMMUNICATIONS, v.14, no.1

ISSN
2041-1723
DOI
10.1038/s41467-023-39545-8
URI
http://hdl.handle.net/10203/311696
Appears in Collection
BC-Journal Papers(저널논문)
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