Bioresorbable, wireless, and battery-free system for electrotherapy and impedance sensing at wound sites

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Chronic wounds, particularly those associated with diabetes mellitus, represent a growing threat to public health, with additional notable economic impacts. Inflammation associated with these wounds leads to abnormalities in endogenous electrical signals that impede the migration of keratinocytes needed to support the healing process. This observation motivates the treatment of chronic wounds with electrical stimulation therapy, but practical engineering challenges, difficulties in removing stimulation hardware from the wound site, and absence of means to monitor the healing process create barriers to widespread clinical use. Here, we demonstrate a miniaturized wireless, battery-free bioresorbable electrotherapy system that overcomes these challenges. Studies based on a splinted diabetic mouse wound model confirm the efficacy for accelerated wound closure by guiding epithelial migration, modulating inflammation, and promoting vasculogenesis. Changes in the impedance provide means for tracking the healing process. The results demonstrate a simple and effective platform for wound site electrotherapy.
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Issue Date
2023-02
Language
English
Article Type
Article
Citation

SCIENCE ADVANCES, v.9, no.8

ISSN
2375-2548
DOI
10.1126/sciadv.ade4687
URI
http://hdl.handle.net/10203/306097
Appears in Collection
EE-Journal Papers(저널논문)
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